ArticleThe EMBO journal2002
Sequence-specific interaction of U1 snRNA with the SMN complex.
Article in The EMBO journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed, 81 citations in OpenAlex.
- A guide to the biogenesis and functions of endogenous small non-coding RNAs in animals.Nature reviews. Molecular cell biology · 2025Review
- Examining the capacity of human U1 snRNA variants to facilitate pre-mRNA splicing.RNA (New York, N.Y.) · 2024Article
- The role of survival motor neuron protein (SMN) in protein homeostasis.Cellular and molecular life sciences : CMLS · 2018Review
- A Preliminary Study: PS1 Increases U1 snRNA Expression Associated with AD.Journal of molecular neuroscience : MN · 2017Article
- Article
- Evolution, immunity and the emergence of brain superautoantigens.F1000Research · 2017Article
- Structural basis for snRNA recognition by the double-WD40 repeat domain of Gemin5.Genes & development · 2016Article
- Structural insights into Gemin5-guided selection of pre-snRNAs for snRNP assembly.Genes & development · 2016Article
- A U1 snRNP-specific assembly pathway reveals the SMN complex as a versatile hub for RNP exchange.Nature structural & molecular biology · 2016Article
- Intrinsically disordered proteins in the nucleus of human cells.Biochemistry and biophysics reports · 2015Article
- Stem-loop 4 of U1 snRNA is essential for splicing and interacts with the U2 snRNP-specific SF3A1 protein during spliceosome assembly.Genes & development · 2014Article
- SMN control of RNP assembly: from post-transcriptional gene regulation to motor neuron disease.Seminars in cell & developmental biology · 2014Review
- Identification of truncated forms of U1 snRNA reveals a novel RNA degradation pathway during snRNP biogenesis.Nucleic acids research · 2014Article
- Spinal muscular atrophy: an update on therapeutic progress.Biochimica et biophysica acta · 2013Review
- Implication of the SMN complex in the biogenesis and steady state level of the signal recognition particle.Nucleic acids research · 2013Article
- FUS-SMN protein interactions link the motor neuron diseases ALS and SMA.Cell reports · 2012Article
- Gemin5 delivers snRNA precursors to the SMN complex for snRNP biogenesis.Molecular cell · 2010Article
- Efficient transcription through an intron requires the binding of an Sm-type U1 snRNP with intact stem loop II to the splice donor.Nucleic acids research · 2010Article
- Role of survival motor neuron complex components in small nuclear ribonucleoprotein assembly.The Journal of biological chemistry · 2009Article
- Gemin5-snRNA interaction reveals an RNA binding function for WD repeat domains.Nature structural & molecular biology · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The survival of motor neurons (SMN) protein complex functions in the biogenesis of spliceosomal small nuclear ribonucleoprotein particles (snRNPs) and prob ably other RNPs. All spliceosomal snRNPs have a common core of seven Sm proteins. To mediate the assembly of snRNPs, the SMN complex must be able to bring together Sm proteins with U snRNAs. We showed previously that SMN and other components of the SMN complex interact directly with several Sm proteins. Here, we show that the SMN complex also interacts specifically with U1 snRNA. The stem--loop 1 domain of U1 (SL1) is necessary and sufficient for SMN complex binding in vivo and in vitro. Substitution of three nucleotides in the SL1 loop (SL1A3) abolishes SMN interaction, and the corresponding U1 snRNA (U1A3) is impaired in U1 snRNP biogenesis. Microinjection of excess SL1 but not SL1A3 into Xenopus oocytes inhibits SMN complex binding to U1 snRNA and U1 snRNP assembly. These findings indicate that SMN complex interaction with SL1 is sequence-specific and critical for U1 snRNP biogenesis, further supporting the direct role of the SMN complex in RNP biogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.