ArticleBiophysical journal2002
Effects of quercetin on single Ca(2+) release channel behavior of skeletal muscle.
Article in Biophysical journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 47 citations in OpenAlex.
- Acute kaempferol ingestion lowers oxygen uptake during submaximal exercise and improves high-intensity exercise capacity in well-trained male athletes.Physiological reports · 2025Trial
- Acute effects of caffeine or quercetin ingestion on motor unit firing pattern before and after resistance exercise.European journal of applied physiology · 2024Trial
- The Effects of Quercetin Supplementation on Eccentric Exercise-Induced Muscle Damage.Nutrients · 2019Trial
- The acute effect of Quercetin on muscle performance following a single resistance training session.European journal of applied physiology · 2018Trial
- Kaempferol Reduces Cardiopulmonary Load and Muscular Damage in Repeated 400-m Sprints: A Double-Blind, Randomized, Placebo-Controlled Trial.Food science & nutrition · 2024Article
- The dose-response relationship of quercetin on the motor unit firing patterns and contractile properties of muscle in men and women.Journal of the International Society of Sports Nutrition · 2023Article
- Identification of Potential Human Ryanodine Receptor 1 Agonists and Molecular Mechanisms of Natural Small-Molecule Phenols as Anxiolytics.ACS omega · 2021Article
- Quercetin ingestion modifies human motor unit firing patterns and muscle contractile properties.Experimental brain research · 2021Article
- RyR1-targeted drug discovery pipeline integrating FRET-based high-throughput screening and human myofiber dynamic CaScientific reports · 2020Article
- Article
- Quercetin Enhances Inhibitory Synaptic Inputs and Reduces Excitatory Synaptic Inputs to OFF- and ON-Type Retinal Ganglion Cells in a Chronic Glaucoma Rat Model.Frontiers in neuroscience · 2019Article
- Effect of Novel Quercetin Titanium Dioxide-Decorated Multi-Walled Carbon Nanotubes Nanocomposite on Bacillus subtilis Biofilm Development.Materials (Basel, Switzerland) · 2018Article
- Quercetin as a fluorescent probe for the ryanodine receptor activity in Jurkat cells.Pflugers Archiv : European journal of physiology · 2013Article
- Both basic and acidic amino acid residues of IpTx(a) are involved in triggering substate of RyR1.Journal of biomedicine & biotechnology · 2011Article
- Phenol increases intracellular [Ca2+] during twitch contractions in intact Xenopus skeletal myofibers.Journal of applied physiology (Bethesda, Md. : 1985) · 2010Article
- Temporal switching and cell-to-cell variability in Ca2+ release activity in mammalian cells.Molecular systems biology · 2009Article
- A two-gate model for the ryanodine receptor with allosteric modulation by caffeine and quercetin.European biophysics journal : EBJ · 2008Article
- Aldolase potentiates DIDS activation of the ryanodine receptor in rabbit skeletal sarcoplasmic reticulum.The Biochemical journal · 2006Article
- Calcium activation of ryanodine receptor channels--reconciling RyR gating models with tetrameric channel structure.The Journal of general physiology · 2005Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Quercetin, a bioflavonoid, is known to affect Ca(2+) fluxes in sarcoplasmic reticulum, although its direct effect on Ca(2+) release channel (CRC) in sarcoplasmic reticulum has remained to be elucidated. The present study examined the effect of quercetin on the behavior of single skeletal CRC in planar lipid bilayer. The effect of caffeine was also studied for comparison. At very low [Ca(2+)](cis) (80 pM), quercetin activated CRC marginally, whereas at elevated [Ca(2+)](cis) (10 microM), both open probability (P(o)) and sensitivity to the drug increased markedly. Caffeine showed a similar tendency. Analysis of lifetimes for single CRC showed that quercetin and caffeine led to different mean open-time and closed-time constants and their proportions. Addition of 10 microM ryanodine to CRC activated by quercetin or caffeine led to the typical subconductance state (approximately 54%) and a subsequent addition of 5 microM ruthenium red completely blocked CRC activity. When 6 microM quercetin and 3 mM caffeine were added together to the cis side of CRC, a time-dependent increase of P(o) was observed (from mode 1 (0.376 +/- 0.043, n = 5) to mode 2 (0.854 +/- 0.062, n = 5)). On the other hand, no further activation was observed when quercetin was added after caffeine. Quercetin affected only the ascending phase of the bell-shaped Ca(2+) activation/inactivation curve, whereas caffeine affected both ascending and descending phases. [(3)H]ryanodine binding to sarcoplasmic reticulum showed that channel activity increased more by both quercetin and caffeine than by caffeine alone. These characteristic differences in the modes of activation of CRC by quercetin and caffeine suggest that the channel activation mechanisms and presumably the binding sites on CRC are different for the two drugs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.