ArticleBiophysical journal2002
The brownian ratchet and power stroke models for posttranslational protein translocation into the endoplasmic reticulum.
Article in Biophysical journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Experimental study of a nanoscale translocation ratchet.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Conformational fluctuations of a DNA electrophoretically translocating through a nanopore under the action of a motor protein.The European physical journal. E, Soft matter · 2019Article
- Review
- Quantifying the role of chaperones in protein translocation by computational modeling.Frontiers in molecular biosciences · 2015Article
- The similarity between N-terminal targeting signals for protein import into different organelles and its evolutionary relevance.Frontiers in physiology · 2015Review
- BiP clustering facilitates protein folding in the endoplasmic reticulum.PLoS computational biology · 2014Article
- A Brownian ratchet for protein translocation including dissociation of ratcheting sites.Journal of mathematical biology · 2013Article
- Spatial localisation of chaperone distribution in the endoplasmic reticulum of yeast.IET systems biology · 2012Article
- A top-down approach to mechanistic biological modeling: application to the single-chain antibody folding pathway.Biophysical journal · 2008Article
- Exact steady-state velocity of ratchets driven by random sequential adsorption.Journal of physics A: Mathematical and general · 2007Article
- A novel approach for N-glycosylation studies using detergent extracted microsomes.Molecular and cellular biochemistry · 2005Article
- What drives the translocation of stiff chains?Proceedings of the National Academy of Sciences of the United States of America · 2003Article
Corrections and comments
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Authors and funding
1 author.
Funding
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Abstract
A quantitative analysis of experimental data for posttranslational translocation into the endoplasmic reticulum is performed. This analysis reveals that translocation involves a single rate-limiting step, which is postulated to be the release of the signal sequence from the translocation channel. Next, the Brownian ratchet and power stroke models of translocation are compared against the data. The data sets are simultaneously fit using a least-squares criterion, and both models are found to accurately reproduce the experimental results. A likelihood-ratio test reveals that the optimal fit of the Brownian ratchet model, which contains one fewer free parameter, does not differ significantly from that of the power stroke model. Therefore, the data considered here cannot be used to reject this import mechanism. The models are further analyzed using the estimated parameters to make experimentally testable predictions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.