ArticleMolecular and cellular biology2002
Coupling of enhancer and insulator properties identified in two retrotransposons modulates their mutagenic impact on nearby genes.
Article in Molecular and cellular biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 47 citations in OpenAlex.
- Review
- "What You Need, Baby, I Got It": Transposable Elements as Suppliers of Cis-Operating Sequences in Drosophila.Biology · 2020Review
- Transcriptionally promiscuous "blurry" promoters in Tc1/Mobile DNA · 2019Article
- Expanding the roles of chromatin insulators in nuclear architecture, chromatin organization and genome function.Cellular and molecular life sciences : CMLS · 2014Review
- Making connections: insulators organize eukaryotic chromosomes into independent cis-regulatory networks.BioEssays : news and reviews in molecular, cellular and developmental biology · 2014Review
- Effective blocking of the white enhancer requires cooperation between two main mechanisms suggested for the insulator function.PLoS genetics · 2013Article
- Functional analysis of the HS185 regulatory element in the rice HSP70 promoter.Molecular biology reports · 2012Article
- Drosophila errantiviruses.Mobile genetic elements · 2012Article
- Mosquitoes LTR retrotransposons: a deeper view into the genomic sequence of Culex quinquefasciatus.PloS one · 2012Article
- Cis-regulatory elements: molecular mechanisms and evolutionary processes underlying divergence.Nature reviews. Genetics · 2011Review
- Article
- Evidences for insulator activity of the 5'UTR of the Drosophila melanogaster LTR-retrotransposon ZAM.Molecular genetics and genomics : MGG · 2010Article
- A transformation booster sequence (TBS) from Petunia hybrida functions as an enhancer-blocking insulator in Arabidopsis thaliana.Plant cell reports · 2009Article
- Orientation-dependent interaction between Drosophila insulators is a property of this class of regulatory elements.Nucleic acids research · 2008Article
- Enhancer-promoter communication is regulated by insulator pairing in a Drosophila model bigenic locus.Molecular and cellular biology · 2008Article
- Red flag on the white reporter: a versatile insulator abuts the white gene in Drosophila and is omnipresent in mini-white constructs.Nucleic acids research · 2008Article
- New properties of Drosophila fab-7 insulator.Genetics · 2007Article
- Unravelling the world of cis-regulatory elements.Medical & biological engineering & computing · 2007Review
- Article
- Idefix insulator activity can be modulated by nearby regulatory elements.Nucleic acids research · 2007Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We recently reported a novel transposition system in which two retroelements from Drosophila melanogaster, ZAM and Idefix, are highly mobilized and preferentially insert within intergenic regions. Among the loci where new copies are detected, a hot spot for their insertion was identified at the white locus, where up to three elements occurred within a 3-kb fragment upstream of the transcriptional start site of white. We have used these insertions as molecular entry points to throw light on the mutagenic effect exerted by multiple insertions of retrotransposons within intergenic regions of a genome. Analysis of the molecular mechanisms by which ZAM and Idefix elements interfere with the regulation of the white gene has shown that ZAM bears cis-acting regulatory sequences able to enhance transcription of the white gene in the eyes of the flies. This activation may be counteracted by Idefix, which acts as an insulator able to isolate the white gene from the upstream ZAM enhancer. In addition to revealing a novel insulator sequence with its own specific features, our data clearly illustrate how retroelements can act as epigenetic factors able to interfere with the transcriptional regulation of their host.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.