ArticleThe Journal of general physiology2002
Single ion occupancy and steady-state gating of Na channels in squid giant axon.
Article in The Journal of general physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed.
- Molecular Dynamics Simulations of Ion Permeation in Human Voltage-Gated Sodium Channels.Journal of chemical theory and computation · 2023Article
- Selective ion permeation involves complexation with carboxylates and lysine in a model human sodium channel.PLoS computational biology · 2018Article
- Sodium channel biophysics, late sodium current and genetic arrhythmic syndromes.Pflugers Archiv : European journal of physiology · 2017Review
- Sequence variations at I260 and A1731 contribute to persistent currents in Drosophila sodium channels.Neuroscience · 2014Article
- Molecular dynamics of ion transport through the open conformation of a bacterial voltage-gated sodium channel.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Current and selectivity in a model sodium channel under physiological conditions: Dynamic Monte Carlo simulations.Biochimica et biophysica acta · 2012Article
- Energy variational analysis of ions in water and channels: Field theory for primitive models of complex ionic fluids.The Journal of chemical physics · 2010Article
- Brownian dynamics study of flux ratios in sodium channels.European biophysics journal : EBJ · 2008Article
- Steric selectivity in Na channels arising from protein polarization and mobile side chains.Biophysical journal · 2007Article
- Sodium flux ratio in Na/K pump-channels opened by palytoxin.The Journal of general physiology · 2007Article
- Persistent tetrodotoxin-sensitive sodium current resulting from U-to-C RNA editing of an insect sodium channel.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
Abstract
The properties of the small fraction of tetrodotoxin (TTX)-sensitive Na channels that remain open in the steady state were studied in internally dialyzed voltage clamped squid giant axons. The observed Ussing flux ratio exponent (n') of 0.97 plus minus 0.03 (calculated from simultaneous measurements of TTX-sensitive current and (22)Na efflux) and nonindependent behavior of Na current at high internal [Na] are explained by a one-site ("1s") permeation model characterized by a single effective binding site within the channel pore in equilibrium with internal Na ions (apparent equilibrium dissociation constant K(Nai)(0) = 0.61 +/- 0.08 M). Steady-state open probability of the TTX-sensitive channels can be modeled by the product p(a)p(infinity), where p(a) represents voltage-dependent activation described by a Boltzmann distribution with midpoint V(a) = -7 mV and effective valence z(a) = 3.2 (Vandenberg, C.A., and F. Bezanilla. 1991. BIOPHYS: J. 60:1499--1510) coupled to voltage-independent inactivation by an equilibrium constant (Bezanilla, F., and C.M. Armstrong. 1977. J. Gen. Physiol. 70:549--566) K(eq) = 770. The factor p(infinity) represents voltage-dependent inactivation with empirical midpoint V(infinity)= -83 plus minus 5 mV and effective valence z(infinity) = 0.55 plus minus 0.03. The composite p(a)p(infinity)1s model describes the steady-state voltage dependence of the persistent TTX-sensitive current well.
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