ArticleGenetics2002
Efficient mobilization of mariner in vivo requires multiple internal sequences.
Article in Genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Affinities of Terminal Inverted Repeats to DNA Binding Domain of Transposase Affect the Transposition Activity of BambooInternational journal of molecular sciences · 2019Article
- Mariner transposons are sailing in the genome of the blood-sucking bug Rhodnius prolixus.BMC genomics · 2015Article
- Random and targeted transgene insertion in Caenorhabditis elegans using a modified Mos1 transposon.Nature methods · 2014Article
- Review
- Physical properties of DNA components affecting the transposition efficiency of the mariner Mos1 element.Molecular genetics and genomics : MGG · 2009Article
- The bacterial Tn9 chloramphenicol resistance gene: an attractive DNA segment for Mos1 mariner insertions.Molecular genetics and genomics : MGG · 2009Article
- Factors acting on Mos1 transposition efficiency.BMC molecular biology · 2008Article
- Post-integration behavior of a Minos transposon in the malaria mosquito Anopheles stephensi.Molecular genetics and genomics : MGG · 2007Article
- Evolution of full-length and deleted forms of the mariner-like element, Botmar1, in the Genome of the bumble bee, Bombus terrestris (Hymenoptera: Apidae).Journal of molecular evolution · 2005Article
- Characterization of Mos1-mediated mutagenesis in Caenorhabditis elegans: a method for the rapid identification of mutated genes.Genetics · 2005Article
- Analyses of cis -acting elements that affect the transposition of Mos1 mariner transposons in vivo.Molecular genetics and genomics : MGG · 2004Article
- The Frog Prince: a reconstructed transposon from Rana pipiens with high transpositional activity in vertebrate cells.Nucleic acids research · 2003Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Aberrant products of mariner excision that have an impaired ability to be mobilized often include internal deletions that do not encroach on either of the inverted repeats. Analysis of 13 such deletions, as well as 7 additional internal deletions obtained by various methods, has revealed at least three internal regions whose integrity is necessary for efficient mariner mobilization. Within the 1286-bp element, the essential regions are contained in the intervals bounded by coordinates 229-586, 735-765, and 939-1066, numbering in base pairs from the extreme 5' end of the element. These regions may contain sequences that are necessary for transposase binding or that are needed to maintain proper spacing between binding sites. The isolation of excision-defective elements with point mutations at nucleotide positions 993 and 161/179 supports the hypothesis of sequence requirements, but the reduced mobility of transformation vectors with insertions into the SacI site at position 790 supports the hypothesis of spacing requirements. The finding of multiple internal regions that are essential for efficient mariner mobilization in vivo contrasts with reports that mini-elements with as little as 43 bp of DNA between the inverted repeats can transpose efficiently in vitro.
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