ArticleCellular and molecular neurobiology2001
Analysis of gene expression following sciatic nerve crush and spinal cord hemisection in the mouse by microarray expression profiling.
Article in Cellular and molecular neurobiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 38 citations in OpenAlex.
- Tumor suppressive effect of low-frequency repetitive transcranial magnetic stimulation on glioblastoma progression.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Article
- Therapeutic effects of polydeoxyribonucleotide in an in vitro neuronal model of ischemia/reperfusion injury.Scientific reports · 2023Article
- Parasympathetic Effect Induces Cell Cycle Activation in Upper Limbs of Paraplegic Patients with Spinal Cord Injury.International journal of molecular sciences · 2019Article
- The alternatively spliced fibronectin CS1 isoform regulates IL-17A levels and mechanical allodynia after peripheral nerve injury.Journal of neuroinflammation · 2015Article
- Flipping the transcriptional switch from myelin inhibition to axon growth in the CNS.Frontiers in molecular neuroscience · 2015Article
- Cell Therapy Augments Functional Recovery Subsequent to Spinal Cord Injury under Experimental Conditions.Stem cells international · 2015Review
- Genome-wide expression profile of the response to spinal cord injury in Xenopus laevis reveals extensive differences between regenerative and non-regenerative stages.Neural development · 2014Article
- Extracellular matrix-associated gene expression in adult sensory neuron populations cultured on a laminin substrate.BMC neuroscience · 2013Article
- Spinal cord trauma and the molecular point of no return.Molecular neurodegeneration · 2012Review
- Mst3b, an Ste20-like kinase, regulates axon regeneration in mature CNS and PNS pathways.Nature neuroscience · 2009Article
- Analysis of gene expression during neurite outgrowth and regeneration.BMC neuroscience · 2007Article
- Mining microarrays for metabolic meaning: nutritional regulation of hypothalamic gene expression.Neurochemical research · 2004Article
- Strategies for identifying genes that play a role in spinal cord regeneration.Journal of anatomy · 2004Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The responses of periphery (PNS) and central nervous systems (CNS) towards nerve injury are different: while injured mammalian periphery nerons can successfully undergo regeneration, axons in the central nervous system are usually not able to regenerate. 2. In the present study, the genes which were differentially expressed in the PNS and CNS following nerve injury were identified and compared by microarray profiling techniques. 3. Sciatic nerve crush and hemisection of the spinal cord of adult mice were used as the models for nerve injury in PNS and CNS respectivey. 4. It was found that of all the genes examined, 14% (80/588) showed changes in expression following either PNS or CNS injury, and only 3% (18/588) showed changes in both types of injuries. 5. Among all the differentially expressed genes, only 8% (6/80) exhibited similar changes in gene expression (either up- or down-regulation) following injury in both PNS and CNS nerve injuries. 6. Our results indicated that microarray expression profiling is an efficient and useful method to identify genes that are involved in the regeneration process following nerve injuries, and several genes which are differentially expressed in the PNS and/or CNS following nerve injuries were identified in the present study.
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