ArticleOncogene2002
Identification of a region of homozygous deletion on 8p22-23.1 in medulloblastoma.
Article in Oncogene, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 32 citations in OpenAlex.
- Cytogenetic characterization of the malignant primitive neuroectodermal SK-PN-DW tumor cell line.BMC cancer · 2019Article
- Genetic differences between Asian and Caucasian chronic lymphocytic leukemia.International journal of oncology · 2013Article
- Biological background of pediatric medulloblastoma and ependymoma: a review from a translational research perspective.Neuro-oncology · 2008Review
- Genome wide copy number abnormalities in pediatric medulloblastomas as assessed by array comparative genome hybridization.Brain pathology (Zurich, Switzerland) · 2007Article
- High-frequency promoter hypermethylation of the deleted in liver cancer-1 gene in multiple myeloma.Journal of clinical pathology · 2006Article
- High-resolution array-based comparative genomic hybridization of medulloblastomas and supratentorial primitive neuroectodermal tumors.Journal of neuropathology and experimental neurology · 2006Article
- Analysis of DLC-1 expression in human breast cancer.Journal of cancer research and clinical oncology · 2003Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To identify critical tumor suppressor loci that are associated with the development of medulloblastoma, we performed a comprehensive genome-wide allelotype analysis in a series of 12 medulloblastomas. Non-random allelic imbalances were identified on chromosomes 7q (58.3%), 8p (66.7%), 16q (58.3%), 17p (58.3%) and 17q (66.7%). Comparative genomic hybridization analysis confirmed that allelic imbalances on 8p, 16q and 17p were due to loss of genetic materials. Finer deletion mapping in an expanded series of 23 medulloblastomas localized the common deletion region on 8p to an interval of 18.14 cM on 8p22-23.2. We then searched within the region of loss on 8p for loci that might contain homozygous deletion using comparative duplex PCR. An overlapping homozygous deletion region was identified in a 1.8 cM interval on 8p22-23.1, between markers D8S520 and D8S1130, in two medulloblastomas. This region of homozygous deletion also encompasses the 1.4 cM minimal deletion region detected on 8p in ductal carcinoma in situ of breast. In conclusion, we reported for the first time a detailed deletion mapping on 8p in medulloblastoma and have identified a region of homozygous deletion on 8p22-23.1 that is likely to contain a critical tumor suppressor gene involved in the development of medulloblastoma.
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