ArticleOncogene2002
Adenovirus E1A requires the yeast SAGA histone acetyltransferase complex and associates with SAGA components Gcn5 and Tra1.
Article in Oncogene, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Cryo-EM structure of the SAGA and NuA4 coactivator subunit Tra1 at 3.7 angstrom resolution.eLife · 2017Article
- Article
- Analysis of Gal4-directed transcription activation using Tra1 mutants selectively defective for interaction with Gal4.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Opposing oncogenic activities of small DNA tumor virus transforming proteins.Trends in microbiology · 2011Review
- Domains of Tra1 important for activator recruitment and transcription coactivator functions of SAGA and NuA4 complexes.Molecular and cellular biology · 2011Article
- Distinct regulatory mechanisms of eukaryotic transcriptional activation by SAGA and TFIID.Biochimica et biophysica acta · 2011Review
- Requirements for E1A dependent transcription in the yeast Saccharomyces cerevisiae.BMC molecular biology · 2009Article
- A high-resolution interaction map of three transcriptional activation domains with a key coactivator from photo-cross-linking and multiplexed mass spectrometry.Angewandte Chemie (International ed. in English) · 2009Article
- Transcriptional adaptor ADA3 of Drosophila melanogaster is required for histone modification, position effect variegation, and transcription.Molecular and cellular biology · 2008Article
- Structure/function analysis of the phosphatidylinositol-3-kinase domain of yeast tra1.Genetics · 2007Article
- Orchestration of chromatin-based processes: mind the TRRAP.Oncogene · 2007Review
- The SAGA continues: expanding the cellular role of a transcriptional co-activator complex.Oncogene · 2007Review
- C-terminal processing of yeast Spt7 occurs in the absence of functional SAGA complex.BMC biochemistry · 2007Article
- In vivo target of a transcriptional activator revealed by fluorescence resonance energy transfer.Genes & development · 2004Article
- Genome-wide analysis of gene expression regulated by the HAT cofactor Trrap in conditional knockout cells.Nucleic acids research · 2003Article
- The adenovirus E1A oncoprotein recruits the cellular TRRAP/GCN5 histone acetyltransferase complex.Oncogene · 2003Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
The budding yeast Saccharomyces cerevisiae was used as a model system to study the function of the adenovirus E1A oncoprotein. Previously we demonstrated that expression of the N-terminal 82 amino acids of E1A in yeast causes pronounced growth inhibition and specifically interferes with SWI/SNF-dependent transcriptional activation. Further genetic analysis identified the yeast transcription factor Adr1 as a high copy suppressor of E1A function. Transcriptional activation by Adr1 requires interaction with co-activator proteins Ada2 and Gcn5, components of histone acetyltransferase complexes including ADA and SAGA. Analysis of mutant alleles revealed that several components of the SAGA complex, including proteins from the Ada, Spt, and Taf classes were required for E1A-induced growth inhibition. Growth inhibition also depended on the Gcn5 histone acetyltransferase, and point mutations within the Gcn5 HAT domain rendered cells E1A-resistant. Also required was SAGA component Tra1, a homologue of the mammalian TRRAP protein which is required for c-myc and E1A induced cellular transformation. Additionally, Gcn5 protein could associate with E1A in vitro in a manner that depended on the N-terminal domain of E1A, and Tra1 protein was co-immunoprecipitated with E1A in vivo. These results indicate a strong requirement for intact SAGA complex for E1A to function in yeast, and suggest a role for SAGA-like complexes in mammalian cell transformation.
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