ArticleGenes and immunity2002
Rheumatoid arthritis association in Colombian population is restricted to HLA-DRB1*04 QRRAA alleles.
Article in Genes and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 49 citations in OpenAlex.
- Article
- Frequency of human leukocyte antigens class II-DR alleles (HLA-DRB1) in Argentinian patients with early arthritis.Clinical rheumatology · 2019Article
- GWAS reveals new recessive loci associated with non-syndromic facial clefting.European journal of medical genetics · 2012Article
- Cardiovascular disease is associated with extra-articular manifestations in patients with rheumatoid arthritis.Clinical rheumatology · 2009Article
- Opposing effects of the D70 mutation and the shared epitope in HLA-DR4 on disease activity and certain disease phenotypes in rheumatoid arthritis.Annals of the rheumatic diseases · 2007Article
- Campora: a young genetic isolate in South Italy.Human heredity · 2007Article
- Severe rheumatoid valvular heart disease.Clinical rheumatology · 2006Article
- Interleukin-1beta polymorphisms in Colombian patients with autoimmune rheumatic diseases.Genes and immunity · 2004Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In most ethnic groups genetic susceptibility to rheumatoid arthritis (RA) is associated with certain HLA-DRB1 alleles encoding a similar sequence motif called the 'shared epitope' (SE) spanning amino acid positions 70 to 74 in the third diversity region of the outermost domain of the HLA-DRB1 molecule. We examined the association of the SE and RA in 83 Colombian women with established RA and 90 healthy controls. The group HLA-DRB1*04 was associated with RA with respect to controls (47% vs 18%, respectively. OR: 4.1, 95%CI: 2.1-8.2, P < 0.001). HLA-DRB1 alleles carrying the SE QRRAA, but not those carrying QKRAA or RRRAA, were associated with disease (OR: 3.7, 95%CI: 1.73-7.83, P = 0.0009). This association was stronger among HLA-DRB1*04 carriers (OR: 23, 95%CI: 1.3-414, P = 0.002). In our population, the SE QRRAA expressed in DRB1*04 alleles appears critical in identifying women with increased susceptibility to RA.
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