ArticleGenes and immunity2002
Association between baseline levels of C-reactive protein (CRP) and a dinucleotide repeat polymorphism in the intron of the CRP gene.
Article in Genes and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 147 citations in OpenAlex.
- Biomarkers as potential treatment targets in inflammatory bowel disease: A systematic review.Canadian journal of gastroenterology & hepatology · 2015Pooled it
- Systematic review of the literature and a case report informing biopsy-proven giant cell arteritis (GCA) with normal C-reactive protein.Clinical rheumatology · 2012Pooled it
- Review
- Oncogenic mechanisms in renal insufficiency.Clinical kidney journal · 2021Review
- C-reactive protein (CRP) polymorphisms and haplotypes are associated with SLE susceptibility and activity but not with serum CRP levels in Mexican population.Clinical rheumatology · 2018Article
- Comparison between different disease activity scores in rheumatoid arthritis: an Egyptian multicenter study.Clinical rheumatology · 2017Article
- C-reactive protein as an available biomarker determining mental component of health-related quality of life among individuals with spinal cord injury.The journal of spinal cord medicine · 2017Article
- Elevated C-reactive protein and self-reported disease activity in systemic lupus erythematosus.Lupus · 2014Article
- C-reactive protein genetic polymorphisms increase susceptibility to HBV-related hepatocellular carcinoma in a Chinese population.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Chronic inflammation and quality of life in older adults: a cross-sectional study using biomarkers to predict emotional and relational outcomes.Health and quality of life outcomes · 2014Article
- C-reactive protein haplotypes and dispositional optimism in obese and nonobese elderly subjects.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2012Article
- C-reactive protein in rheumatology: biology and genetics.Nature reviews. Rheumatology · 2011Review
- Effect of the rs2259816 polymorphism in the HNF1A gene on circulating levels of c-reactive protein and coronary artery disease (the ludwigshafen risk and cardiovascular health study).BMC medical genetics · 2010Article
- Serologic and laboratory markers in prediction of the disease course in inflammatory bowel disease.World journal of gastroenterology · 2010Article
- CRP gene variation and risk of community-acquired pneumonia.Respirology (Carlton, Vic.) · 2010Article
- C-reactive protein as a predictor of disease in smokers and former smokers: a review.International journal of clinical practice · 2009Review
- C-reactive protein genotypes and haplotypes, polymorphisms in NSAID-metabolizing enzymes, and risk of colorectal polyps.Pharmacogenetics and genomics · 2009Article
- Association of MCP-1 -2518 A/G single nucleotide polymorphism with the serum level of CRP in Slovak patients with ischemic heart disease, angina pectoris, and hypertension.Mediators of inflammation · 2009Article
- Nutritional and anti-inflammatory interventions in chronic heart failure.The American journal of cardiology · 2008Review
- Association between serum levels of C-reactive protein and personality traits in women.Behavioral and brain functions : BBF · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Elevation of baseline C-reactive protein (CRP) is associated with increased risk of cardiac disease. This increase might reflect low-grade inflammation, but differences in CRP serum levels might also have a genetic component. To test this possibility, we investigated whether a polymorphic GT-repeat in the intron of the CRP gene contributes to variation in baseline CRP. We found that the polymorphism was associated with differences in baseline CRP in both normal individuals and in patients with the inflammatory disease systemic lupus erythematosus, viz. donors carrying two GT(16) alleles, two GT(21)alleles, or GT(16/21) heterozygotes had two-fold lower serum CRP than those with other genotypes. The frequency of GT(16) and GT(21) was two-fold higher in Caucasians than in African-Americans, but there was no difference in allele distribution between patients and controls. It is not yet known how this genetic polymorphism mediates its effect on CRP expression, and it probably is not a systemic lupus erythematosus susceptibility factor. Rather, the CRP intron polymorphism likely modifies the disease phenotype. On the other hand, the fact that baseline CRP does have a genetic component suggests that in coronary disease, stratification of risk assessment based on CRP levels might be enhanced by consideration of this polymorphism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.