ArticleWorld journal of gastroenterology2001
Taxotere resistance in SUIT Taxotere resistance in pancreatic carcinoma cell line SUIT 2 and its sublines.
Article in World journal of gastroenterology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
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- TUBB3 overexpression has a negligible effect on the sensitivity to taxol in cultured cell lines.Oncotarget · 2017Article
- Microtubule targeting agents: from biophysics to proteomics.Cellular and molecular life sciences : CMLS · 2010Review
- Microtubules and resistance to tubulin-binding agents.Nature reviews. Cancer · 2010Review
- [Biomarkers - the way towards individualized chemotherapy in non-small cell lung cancer (NSCLC)].Wiener medizinische Wochenschrift (1946) · 2007Review
- Predictive factors for response to docetaxel in human breast cancers.Cancer science · 2006Review
- Correlation of CT enhancement, tumor angiogenesis and pathologic grading of pancreatic carcinoma.World journal of gastroenterology · 2003Article
- Inhibitory effects of docetaxel on expression of VEGF, bFGF and MMPs of LS174T cell.World journal of gastroenterology · 2003Article
- Localization of TRAIL/TRAILR in fetal pancreas.World journal of gastroenterology · 2003Article
- K-ras gene mutation in the diagnosis of ultrasound guided fine-needle biopsy of pancreatic masses.World journal of gastroenterology · 2003Article
- Subcellular daunorubicin distribution and its relation to multidrug resistance phenotype in drug-resistant cell line SMMC-7721/R.World journal of gastroenterology · 2002Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the specific mechanisms of intrinsic and acquired resistance to taxotere (TXT) in pancreatic adenocarcinoma (PAC).
methodsMTT assay was used to detect the sensitivity of PAC cell line SUIT-2 and its sublines (S-007, S-013, S-020, S-028 and TXT selected SUIT-2 cell line, S2/TXT) to TXT. Mdr1 (P-gp), multidrug resistance associated protein (MRP), lung resistance protein (LRP) and beta-tubulin isotype gene expressions were detected by RT-PCR. The functionality of P-gp and MRP was tested using their specific blocker verapamil (Ver) and indomethacin (IMC), respectively. The transporter activity of P-gp was also confirmed by Rhodamine 123 accumulation assay.
resultsS-020 and S2/TXT were found to be significantly resistant to TXT(19 and 9.5-fold to their parental cell line SUIT-2, respectively). RT-PCR demonstrated strong expression of Mdr1 in these two cell lines, but weaker expression or no expression in other cells lines. MRP and LRP expressions were found in most of these cell lines. The TXT-resistance in S2-020 and S2/TXT could be reversed almost completely by Ver, but not by IMC. Flow cytometry showed that Ver increased the accumulation of Rhodamine-123 in these two cell lines. Compared with S-020 and SUIT-2, the levels of beta-tubulin isotype II, III expressions in S-2/TXT were increased remarkably.
conclusionThe both intrinsic and acquired TXT-related drug resistance in these PAC cell lines is mainly mediated by P-gp, but had no relationship to MRP and LRP expressions. The increases of beta-tubulin isotype II, III might be collateral changes that occur when the SUIT-2 cells are treated with TXT.
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