ArticleWorld journal of gastroenterology2001
Expression of lipopolysaccharide binding protein and its receptor CD14 in experimental alcoholic liver disease.
Article in World journal of gastroenterology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- ANTI-INFLAMMATORY ACTIVITY OF PLATYCODIN D ON ALCOHOL-INDUCED FATTY LIVER RATS VIA TLR4-MYD88-NF-κB SIGNAL PATH.African journal of traditional, complementary, and alternative medicines : AJTCAM · 2016Article
- Endotoxin and CD14 in the progression of biliary atresia.Journal of translational medicine · 2010Article
- Betaine inhibits toll-like receptor 4 expression in rats with ethanol-induced liver injury.World journal of gastroenterology · 2010Article
- Increased systemic and brain cytokine production and neuroinflammation by endotoxin following ethanol treatment.Journal of neuroinflammation · 2008Article
- Gene expression profiling of alcoholic liver disease in the baboon (Papio hamadryas) and human liver.The American journal of pathology · 2003Article
- Role of mitochondrial dysfunction in hydrogen peroxide-induced apoptosis of intestinal epithelial cells.World journal of gastroenterology · 2003Article
- Synthesis of endotoxin receptor CD14 protein in Kupffer cells and its role in alcohol-induced liver disease.World journal of gastroenterology · 2003Article
- Role of NF-kB in multiple organ dysfunction during acute obstructive cholangitis.World journal of gastroenterology · 2003Article
- Effects of hydrogen peroxide on mitochondrial gene expression of intestinal epithelial cells.World journal of gastroenterology · 2002Article
- Intestinal damage mediated by Kupffer cells in rats with endotoxemia.World journal of gastroenterology · 2002Article
- Expression of CD14 protein and its gene in liver sinusoidal endothelial cells during endotoxemia.World journal of gastroenterology · 2002Article
- Relationship between lymphocyte apoptosis and endotoxin translocation after thermal injury in rats.World journal of gastroenterology · 2002Article
- Liver sinusoidal endothelial cell injury by neutrophils in rats with acute obstructive cholangitis.World journal of gastroenterology · 2002Article
- Nuclear factor kB activity in patients with acute severe cholangitis.World journal of gastroenterology · 2002Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate the relationship between the expression of lipopolysaccharides (LPS) binding protein (LBP) and CD14 mRNA and the severity of liver injury in alcohol-fed rats.
methodsTwenty Wistar rats were divided into two groups:ethanol-fed group (group E) and control group (group C). Group E was fed with ethanol(5-12 g x kg(-1) x d(-1)) and group C received dextrose instead of ethanol. Rats of the two groups were sacrificed at 4 weeks and 8 weeks. Levels of endotoxin and alanine transaminase (ALT) in blood were measured, and liver pathology was observed under light and electronic microscopy. Expressions of LBP and CD14 mRNA in liver tissues were determined by RT-PCR analysis.
resultsPlasma endotoxin levels were increased more significantly in group E(129+/-21) ng x L(-1) and (187+/-35) ng x L(-1) at 4 and 8 wk than in control rats(48+/-9) ng x L(-1) and (53+/-11) ng x L(-1), respectively (P<0.05). Mean values of plasma ALT levels were (1867+/-250) nkat x L(-1) and (2450+/-367) nkat x L(-1) in Group E. The values were increased more dramatically in ethanol-fed rats than in Group C after 4 and 8 weeks. In liver section from ethanol-fed rats, there were marked pathological changes (steatosis, cell infiltration and necrosis). In ethanol-fed rats, ethanol administration led to a significant increase in LBP and CD14 mRNA levels compared with the control group (P<0.05).
conclusionEthanol administration led to a significant increase in endotoxin levels in serum and LBP and CD14 mRNA expressions in liver tissues. The increase of LBP and CD14 mRNA expression might wake the liver more sensitive to endotoxin and liver injury.
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