ArticleWorld journal of gastroenterology2001
SF/HGF-c-Met autocrine and paracrine promote metastasis of hepatocellular carcinoma.
Article in World journal of gastroenterology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- The tumor distance to the main hepatic vessels is a predictor of recurrence-free survival and overall survival in hepatocellular cancer.Langenbeck's archives of surgery · 2025Article
- A phase Ib/II trial of capmatinib plus spartalizumabJHEP reports : innovation in hepatology · 2024Article
- Molecular classification of hepatocellular carcinoma: prognostic importance and clinical applications.Journal of cancer research and clinical oncology · 2022Review
- Gangliosides as Signaling Regulators in Cancer.International journal of molecular sciences · 2021Review
- Oncological benefits of portal vein embolization for patients with hepatocellular carcinoma.Annals of gastroenterological surgery · 2021Review
- Receptor Tyrosine Kinases and Their Signaling Pathways as Therapeutic Targets of Curcumin in Cancer.Frontiers in pharmacology · 2021Review
- The Function of the HGF/c-Met Axis in Hepatocellular Carcinoma.Frontiers in cell and developmental biology · 2020Review
- Capsaicin: Effects on the Pathogenesis of Hepatocellular Carcinoma.Molecules (Basel, Switzerland) · 2019Review
- The role of hepatocyte growth factor in corneal wound healing.Experimental eye research · 2018Review
- Input of microenvironmental regulation on colorectal cancer: role of the CCN family.World journal of gastroenterology · 2014Review
- BMP9 is a proliferative and survival factor for human hepatocellular carcinoma cells.PloS one · 2013Article
- Epigenetic upregulation of HGF and c-Met drives metastasis in hepatocellular carcinoma.PloS one · 2013Article
- Hepatocyte growth factor upregulation promotes carcinogenesis and epithelial-mesenchymal transition in hepatocellular carcinoma via Akt and COX-2 pathways.Clinical & experimental metastasis · 2011Article
- Epithelial-to-mesenchymal transition of murine liver tumor cells promotes invasion.Hepatology (Baltimore, Md.) · 2010Article
- The MET receptor tyrosine kinase is a potential novel therapeutic target for head and neck squamous cell carcinoma.Cancer research · 2009Article
- Genetically modified animal models recapitulating molecular events altered in human hepatocarcinogenesis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2009Review
- The membrane-cytoskeleton organizer ezrin is necessary for hepatocellular carcinoma cell growth and invasiveness.Journal of cancer research and clinical oncology · 2006Article
- Expression of IGF-II in early experimental hepatocellular carcinomas and its significance in early diagnosis.World journal of gastroenterology · 2003Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo explore the role of SF/HGF-Met autocrine and paracrine in metastasis of hepatocellular carcinoma (HCC).
methodsSF/HGF and c-met transcription and protein expression in HCC were examined by RT-PCR and Western Blot in 4 HCC cell lines, including HepG2, Hep3B, SMMC7721 and MHCC-1, the last cell line had a higher potential of metastasis. sf/hgf cDNA was transfected by the method of Lipofectin into SMMC7721. SF/HGF and c-met antibody were used to stimulate and block SF/HGF-c-met signal transduction. Cell morphology, mobility, and proliferation were respectively compared by microscopic observation, wound healing assay and cell growth curve.
resultsHCC malignancy appeared to be relative to its met-SF/HGF expression. In MHCC-1, c-met expression was much stronger than that in other cell lines with lower potential of metastasis and only SF/HGF autocrine existed in MHCC-1. After sf/hgf cDNA transfection or conditioned medium of MHCC-1 stimulation, SMMC7721 changed into elongated morphology, and the abilities of proliferation (P < 0.05) and mobility increased. Such bio-activity could be blocked by c-met antibody (P < 0.05).
conclusionThe system of SF/HGF-c-met autocrine and paracrine played an important role in development and metastasis potential of HCC. Inhibition of SF/HGF-c-met signal transduction system may reduce the growth and metastasis of HCC.
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