ArticleWorld journal of gastroenterology2001
Human papillomavirus 16 E6 is associated with the nuclear matrix of esophageal carcinoma cells.
Article in World journal of gastroenterology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Possible Oncogenic Viruses Associated with Lung Cancer.OncoTargets and therapy · 2020Review
- Transformation-induced changes in the DNA-nuclear matrix interface, revealed by high-throughput analysis of DNA halos.Scientific reports · 2017Article
- Phase-contrast X-ray CT imaging of esophagus and esophageal carcinoma.Scientific reports · 2014Article
- Integration of human papillomavirus 18 DNA in esophageal carcinoma 109 cells.World journal of gastroenterology · 2011Article
- Human papillomavirus in squamous cell carcinoma of esophagus in a high-risk population.World journal of gastroenterology · 2005Article
- Comparison of nuclear matrix proteins between gastric cancer and normal gastric tissue.World journal of gastroenterology · 2004Article
- Separation and identification of differentially expressed nuclear matrix proteins between human esophageal immortalized and carcinomatous cell lines.World journal of gastroenterology · 2003Article
- Detection of human papillomavirus in Chinese esophageal squamous cell carcinoma and its adjacent normal epithelium.World journal of gastroenterology · 2003Article
- Preoperative TN staging of esophageal cancer: comparison of miniprobe ultrasonography, spiral CT and MRI.World journal of gastroenterology · 2003Article
- Identification of differentially expressed proteins between human esophageal immortalized and carcinomatous cell lines by two-dimensional electrophoresis and MALDI-TOF-mass spectrometry.World journal of gastroenterology · 2002Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo explore the etiologic role of HPV infection in esophageal carcinoma, and the association of HPV-16 E6 with the nuclear matrix of carcinoma cells.
methodsTwo esophageal carcinoma cell lines,EC/CUHK1 and EC/CUHK2, were tested for HPV-16 E6 subgenetic fragment by polymerase chain reaction amplification of virus DNA associated nuclear matrix. RT-PCR and immunocytochemistry were also used to visualize the expression of E6 subgene in the cells.
resultsThe HPV-16 E6 subgenetic fragment was found to be present in nuclear matrix-associated DNA, E6 oncoprotein localized in the nucleus where it is tightly associated with nuclear matrix after sequential extraction in EC/CUHK2 cells. It was not detected, however, in EC/CUHK1 cells.
conclusionThe interaction between HPV-16 E6 and nuclear matrix may contribute to the virus induced carcinogenesis in esophageal carcinoma.
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