ArticleProceedings of the National Academy of Sciences of the United States of America2002
tRNA-like recognition of group I introns by a tyrosyl-tRNA synthetase.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- Review
- Article
- Analysis of RNA structure using small-angle X-ray scattering.Methods (San Diego, Calif.) · 2017Article
- Evolution of RNA-protein interactions: non-specific binding led to RNA splicing activity of fungal mitochondrial tyrosyl-tRNA synthetases.PLoS biology · 2014Article
- Human mitochondrial leucyl tRNA synthetase can suppress non cognate pathogenic mt-tRNA mutations.EMBO molecular medicine · 2014Article
- Emergence and evolution.Topics in current chemistry · 2014Review
- NMR Structure of the C-terminal domain of a tyrosyl-tRNA synthetase that functions in group I intron splicing.Biochemistry · 2011Article
- A phage RNA-binding protein binds to a non-cognate structured RNA and stabilizes its core structure.Biochemical and biophysical research communications · 2009Article
- Toward predicting self-splicing and protein-facilitated splicing of group I introns.RNA (New York, N.Y.) · 2008Article
- Virus-encoded aminoacyl-tRNA synthetases: structural and functional characterization of mimivirus TyrRS and MetRS.Journal of virology · 2007Article
- Functional and crystal structure analysis of active site adaptations of a potent anti-angiogenic human tRNA synthetase.Structure (London, England : 1993) · 2007Article
- Two conformations of a crystalline human tRNA synthetase-tRNA complex: implications for protein synthesis.The EMBO journal · 2006Article
- A C-terminal fragment of an intron-encoded maturase is sufficient for promoting group I intron splicing.RNA (New York, N.Y.) · 2005Article
- Influence of RNA structural stability on the RNA chaperone activity of the Escherichia coli protein StpA.Nucleic acids research · 2005Article
- Division of labor among the yeast Sol proteins implicated in tRNA nuclear export and carbohydrate metabolism.Genetics · 2004Article
- Long-term evolution of the S788 fungal nuclear small subunit rRNA group I introns.RNA (New York, N.Y.) · 2004Article
- The Neurospora crassa CYT-18 protein C-terminal RNA-binding domain helps stabilize interdomain tertiary interactions in group I introns.RNA (New York, N.Y.) · 2004Article
- An inserted region of leucyl-tRNA synthetase plays a critical role in group I intron splicing.The EMBO journal · 2002Article
- Aminoacyl-tRNA synthetases: versatile players in the changing theater of translation.RNA (New York, N.Y.) · 2002Review
- Class I tyrosyl-tRNA synthetase has a class II mode of cognate tRNA recognition.The EMBO journal · 2002Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The Neurospora crassa mitochondrial tyrosyl-tRNA synthetase (CYT-18 protein) functions in splicing group I introns by promoting the formation of the catalytically active RNA structure. Previous work suggested that CYT-18 recognizes a conserved tRNA-like structure of the group I intron catalytic core. Here, directed hydroxyl-radical cleavage assays show that the nucleotide-binding fold and C-terminal domains of CYT-18 interact with the expected group I intron cognates of the aminoacyl-acceptor stem and D-anticodon arms, respectively. Further, three-dimensional graphic modeling, supported by biochemical data, shows that conserved regions of group I introns can be superimposed over interacting regions of the tRNA in a Thermus thermophilus TyrRS/tRNA(Tyr) cocrystal structure. Our results support the hypothesis that CYT-18 and other aminoacyl-tRNA synthetases interact with group I introns by recognizing conserved tRNA-like structural features of the intron RNAs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.