ArticleProceedings of the National Academy of Sciences of the United States of America2002
The interaction between the coactivator dCBP and Modulo, a chromatin-associated factor, affects segmentation and melanotic tumor formation in Drosophila.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Zika virus infection drives epigenetic modulation of immunity by the histone acetyltransferase CBP of Aedes aegypti.PLoS neglected tropical diseases · 2022Article
- Analysis of Drosophila melanogaster proteome dynamics during embryonic development by a combination of label-free proteomics approaches.Proteomics · 2016Article
- A graphical model method for integrating multiple sources of genome-scale data.Statistical applications in genetics and molecular biology · 2013Article
- Corepressive action of CBP on androgen receptor transactivation in pericentric heterochromatin in a Drosophila experimental model system.Molecular and cellular biology · 2009Article
- Drosophila dCBP is involved in establishing the DNA replication checkpoint.Molecular and cellular biology · 2007Article
- Transcriptional regulation by Modulo integrates meiosis and spermatid differentiation in male germ line.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Biological functions of the ISWI chromatin remodeling complex NURF.Genes & development · 2002Article
- Heterochromatin-mediated gene silencing is not affected by Drosophila CBP activity.The Journal of heredityArticle
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of Drosophila requires the function of the CREB-binding protein, dCBP. In flies, dCBP serves as a coactivator for the transcription factors Cubitus interruptus, Dorsal, and Mad, and as a cosuppressor of Drosophila T cell factor. Current models propose that CBP, through its intrinsic and associated histone acetyltransferase activities, affects transient chromatin changes that allow the preinitiation complex to access the promoter. In this report, we provide evidence that dCBP may regulate the formation of chromatin states through interactions with the modulo (mod) gene product, a protein that is thought to be involved in chromatin packaging. We demonstrate that dCBP and Modulo bind in vitro and in vivo, that mutations in mod enhance the embryonic phenotype of a dCBP mutation, and that dCBP mutations enhance the melanotic tumor phenotype characteristic of mod homozygous mutants. These results imply that, in addition to its histone acetyltransferase activity, dCBP may affect higher-order chromatin structure.
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