ArticleMolecular biology of the cell2002
Golgi vesicle proteins are linked to the assembly of an actin complex defined by mAbp1.
Article in Molecular biology of the cell, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 114 citations in OpenAlex.
- Breast cancer bone metastasis and bone metastatic cells retain NKG2DLs intracellularly: could this be a strategy to evade immune recognition?Frontiers in cell and developmental biology · 2026Article
- Dbnl and β-catenin promote pro-N-cadherin processing to maintain apico-basal polarity.The Journal of cell biology · 2021Article
- Cross-Kingdom Activation ofJournal of bacteriology · 2020Review
- Review
- Proteomic analysis of protein interactions between Eimeria maxima sporozoites and chicken jejunal epithelial cells by shotgun LC-MS/MS.Parasites & vectors · 2018Article
- TMED10 Protein Interferes with Transforming Growth Factor (TGF)-β Signaling by Disrupting TGF-β Receptor Complex Formation.The Journal of biological chemistry · 2017Article
- siRNA Screen Identifies Trafficking Host Factors that Modulate Alphavirus Infection.PLoS pathogens · 2016Article
- Rho GTPases, phosphoinositides, and actin: a tripartite framework for efficient vesicular trafficking.Small GTPases · 2014Review
- ARF1-regulated coatomer directs the steady-state localization of protein kinase C epsilon at the Golgi apparatus.Biochimica et biophysica acta · 2013Article
- Regulation of late endosomal/lysosomal maturation and trafficking by cortactin affects Golgi morphology.Cytoskeleton (Hoboken, N.J.) · 2012Article
- Transport of influenza virus neuraminidase (NA) to host cell surface is regulated by ARHGAP21 and Cdc42 proteins.The Journal of biological chemistry · 2012Article
- p23/Tmp21 associates with protein kinase Cdelta (PKCdelta) and modulates its apoptotic function.The Journal of biological chemistry · 2011Article
- Article
- Article
- Cdc42 regulates microtubule-dependent Golgi positioning.Traffic (Copenhagen, Denmark) · 2010Article
- p23/Tmp21 differentially targets the Rac-GAP beta2-chimaerin and protein kinase C via their C1 domains.Molecular biology of the cell · 2010Article
- Protein complexes containing CYFIP/Sra/PIR121 coordinate Arf1 and Rac1 signalling during clathrin-AP-1-coated carrier biogenesis at the TGN.Nature cell biology · 2010Article
- Chemico-genetic identification of drebrin as a regulator of calcium responses.The international journal of biochemistry & cell biology · 2010Article
- The association of the Arabidopsis actin-related protein2/3 complex with cell membranes is linked to its assembly status but not its activation.Plant physiology · 2009Article
- In vivo roles for Arp2/3 in cortical actin organization during C. elegans gastrulation.Journal of cell science · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies indicate that regulation of the actin cytoskeleton is important for protein trafficking, but its precise role is unclear. We have characterized the ARF1-dependent assembly of actin on the Golgi apparatus. Actin recruitment involves Cdc42/Rac and requires the activation of the Arp2/3 complex. Although the actin-binding proteins mAbp1 (SH3p7) and drebrin share sequence homology, they are differentially segregated into two distinct ARF-dependent actin complexes. The binding of Cdc42 and mAbp1, which localize to the Golgi apparatus, but not drebrin, is blocked by occupation of the p23 cargo-protein-binding site on coatomer. Exogenously expressed mAbp1 is mislocalized and inhibits Golgi transport in whole cells. The ability of ARF, vesicle-coat proteins, and cargo to direct the assembly of cytoskeletal structures helps explain how only a handful of vesicle types can mediate the numerous trafficking steps in the cell.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.