ArticleMolecular biology of the cell2002
Drosophila minichromosome maintenance 6 is required for chorion gene amplification and genomic replication.
Article in Molecular biology of the cell, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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41 citing papers in PubMed, 68 citations in OpenAlex.
- Comparative Transcriptomic Analyses Identify Candidate Genes for Convergent Reproductive Shifts in a Bimodal Viviparous Amphibian.Molecular ecology · 2026Article
- Premature endocycling of Drosophila follicle cells causes pleiotropic defects in oogenesis.Genetics · 2024Article
- Tissue-Specific DNA Replication Defects inGenetics · 2020Article
- An RNAi Screen for Genes Required for Growth ofG3 (Bethesda, Md.) · 2019Article
- Genome-wide Kdm4 histone demethylase transcriptional regulation in Drosophila.Molecular genetics and genomics : MGG · 2019Article
- Comparative RNA-sequencing analysis of ER-based HSP90 functions and signal pathways in Tribolium castaneum.Cell stress & chaperones · 2018Article
- Rapid DNA Synthesis During EarlyGenetics · 2017Article
- DNA Replication Control DuringGenetics · 2017Review
- Different cell cycle modifications repress apoptosis at different steps independent of developmental signaling in Drosophila.Molecular biology of the cell · 2016Article
- The Histone Variant H3.3 Is Enriched at Drosophila Amplicon Origins but Does Not Mark Them for Activation.G3 (Bethesda, Md.) · 2016Article
- The function of Drosophila p53 isoforms in apoptosis.Cell death and differentiation · 2015Article
- Characterization of a Drosophila ortholog of the Cdc7 kinase: a role for Cdc7 in endoreplication independent of Chiffon.The Journal of biological chemistry · 2015Article
- Low levels of p53 protein and chromatin silencing of p53 target genes repress apoptosis in Drosophila endocycling cells.PLoS genetics · 2014Article
- Induction of endocycles represses apoptosis independently of differentiation and predisposes cells to genome instability.Development (Cambridge, England) · 2014Article
- Genomic markers of ovarian reserve.Seminars in reproductive medicine · 2013Review
- The Drosophila BTB domain protein Jim Lovell has roles in multiple larval and adult behaviors.PloS one · 2013Article
- The histone acetyltransferases CBP and Chameau integrate developmental and DNA replication programs in Drosophila ovarian follicle cells.Development (Cambridge, England) · 2012Article
- Analysis of model replication origins in Drosophila reveals new aspects of the chromatin landscape and its relationship to origin activity and the prereplicative complex.Molecular biology of the cell · 2012Article
- Wolbachia-induced aae-miR-12 miRNA negatively regulates the expression of MCT1 and MCM6 genes in Wolbachia-infected mosquito cell line.PloS one · 2012Article
- The -14010*C variant associated with lactase persistence is located between an Oct-1 and HNF1α binding site and increases lactase promoter activity.Human genetics · 2011Article
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4 authors at 1 institution in 1 country.
Funding
Abstract
Duplication of the eukaryotic genome initiates from multiple origins of DNA replication whose activity is coordinated with the cell cycle. We have been studying the origins of DNA replication that control amplification of eggshell (chorion) genes during Drosophila oogenesis. Mutation of genes required for amplification results in a thin eggshell phenotype, allowing a genetic dissection of origin regulation. Herein, we show that one mutation corresponds to a subunit of the minichromosome maintenance (MCM) complex of proteins, MCM6. The binding of the MCM complex to origins in G1 as part of a prereplicative complex is critical for the cell cycle regulation of origin licensing. We find that MCM6 associates with other MCM subunits during amplification. These results suggest that chorion origins are bound by an amplification complex that contains MCM proteins and therefore resembles the prereplicative complex. Lethal alleles of MCM6 reveal it is essential for mitotic cycles and endocycles, and suggest that its function is mediated by ATP. We discuss the implications of these findings for the role of MCMs in the coordination of DNA replication during the cell cycle.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.