ArticleMolecular biology of the cell2002
Post-cytochrome C protection from apoptosis conferred by a MAPK pathway in Xenopus egg extracts.
Article in Molecular biology of the cell, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 55 citations in OpenAlex.
- Advances in Our Understanding of the Molecular Mechanisms of Action of Cisplatin in Cancer Therapy.Journal of experimental pharmacology · 2021Review
- Toward the understanding of biology of oocyte life cycle inReproductive medicine and biology · 2020Review
- Postovulatory cell death: why eggs die via apoptosis in biological species with external fertilization.The Journal of reproduction and development · 2018Review
- Article
- Signalling mechanisms involved in renal pathological changes during cisplatin-induced nephropathy.European journal of clinical pharmacology · 2013Review
- Unlaid Xenopus eggs degrade by apoptosis in the genital tract.BMC cell biology · 2013Article
- Multimechanistic tumor targeted oncolytic virus overcomes resistance in brain tumors.Molecular therapy : the journal of the American Society of Gene Therapy · 2013Article
- Rsk-mediated phosphorylation and 14-3-3ɛ binding of Apaf-1 suppresses cytochrome c-induced apoptosis.The EMBO journal · 2012Article
- Unfertilized frog eggs die by apoptosis following meiotic exit.BMC cell biology · 2011Article
- Dual-specific phosphatase-6 (Dusp6) and ERK mediate AMPA receptor-induced oligodendrocyte death.The Journal of biological chemistry · 2011Article
- Unfertilized Xenopus eggs die by Bad-dependent apoptosis under the control of Cdk1 and JNK.PloS one · 2011Article
- Raf-1 activation prevents caspase 9 processing downstream of apoptosome formation.Journal of signal transduction · 2011Article
- Article
- The synergistic effect of Mig-6 and Pten ablation on endometrial cancer development and progression.Oncogene · 2010Article
- Restraint of apoptosis during mitosis through interdomain phosphorylation of caspase-2.The EMBO journal · 2009Article
- Inhibition of apoptosis by ascorbic and dehydroascorbic acids inReproductive medicine and biology · 2009Article
- p42MAPK-mediated phosphorylation of xEIAP/XLX in Xenopus cytostatic factor-arrested egg extracts.BMC biochemistry · 2007Article
- Bcr-Abl-mediated protection from apoptosis downstream of mitochondrial cytochrome c release.Molecular and cellular biology · 2004Article
- Induction of apoptosis in starfish eggs requires spontaneous inactivation of MAPK (extracellular signal-regulated kinase) followed by activation of p38MAPK.Molecular biology of the cell · 2004Article
- Critical function of endogenous XIAP in regulating caspase activation during sympathetic neuronal apoptosis.The Journal of cell biology · 2003Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In response to many different apoptotic stimuli, cytochrome c is released from the intermembrane space of the mitochondria into the cytoplasm, where it serves as a cofactor in the activation of procaspase 9. Inhibition of this process can occur either by preventing cytochrome c release or by blocking caspase activation or activity. Experiments involving in vitro reconstitution of apoptosis in cell-free extracts of Xenopus laevis eggs have suggested that extracts arrested in interphase are susceptible to an endogenous apoptotic program leading to caspase activation, whereas extracts arrested in meiotic metaphase are not. We report here that Mos/MEK/MAPK pathways active in M phase-arrested eggs are responsible for rendering them refractory to apoptosis. Interestingly, M phase-arrested extracts are competent to release cytochrome c, yet still do not activate caspases. Concomitantly, we have also demonstrated that recombinant Mos, MEK, and ERK are sufficient to block cytochrome c-dependent caspase activation in purified Xenopus cytosol, which lacks both transcription and translation. These data indicate that the MAP kinase pathway can target and inhibit post-cytochrome c release apoptotic events in the absence of new mRNA/protein synthesis and that this biochemical pathway is responsible for the apoptotic inhibition observed in meiotic X. laevis egg extracts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.