ArticleThe Journal of clinical investigation2002
CD4(+) T cells specific to a glomerular basement membrane antigen mediate glomerulonephritis.
Article in The Journal of clinical investigation, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 141 citations in OpenAlex.
- Butyric Acid-Modified m-P14 Peptide Ameliorates Anti-Glomerular Basement Membrane Disease.International journal of molecular sciences · 2026Article
- Identification of antibodies against phospholipase A2 receptor peptides in PLA2R-associated membranous nephropathy with negative circulating anti-PLA2R antibodies.Frontiers in immunology · 2026Article
- ET-3/ETBR Mediates NaCirculation research · 2025Article
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- Pediatric double-seropositive anti-glomerular basement membrane antibody disease: A case report and literature review.Clinical nephrology. Case studies · 2024Article
- Review
- Pembrolizumab-Induced Anti-GBM Glomerulonephritis: A Case Report.Kidney medicine · 2023Article
- Atypical Anti-Glomerular Basement Membrane Disease.Kidney international reports · 2023Review
- Atypical Antiglomerular Basement Membrane Nephritis Following Immune Checkpoint Inhibitor.Kidney international reports · 2022Article
- Immune cell behaviour and dynamics in the kidney - insights from in vivo imaging.Nature reviews. Nephrology · 2022Review
- Atypical anti-glomerular basement membrane glomerulonephritis in a patient with metastatic melanoma treated with mitogen-activated protein kinase and immune checkpoint inhibitors: a case report.Journal of medical case reports · 2021Article
- Experimental Antiglomerular Basement Membrane GN Induced by a Peptide fromJournal of the American Society of Nephrology : JASN · 2020Article
- Role of CD8+ T cells in crescentic glomerulonephritis.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2020Review
- TNF-α in T lymphocytes attenuates renal injury and fibrosis during nephrotoxic nephritis.American journal of physiology. Renal physiology · 2020Article
- A Modified Peptide Derived from Goodpasture Autoantigen Arrested and Attenuated Kidney Injuries in a Rat Model of Anti-GBM Glomerulonephritis.Journal of the American Society of Nephrology : JASN · 2020Article
- Goodpasture's autoimmune disease - A collagen IV disorder.Matrix biology : journal of the International Society for Matrix Biology · 2018Review
- Antigen-Specificity in the Thymic Development and Peripheral Activity of CD4Frontiers in immunology · 2018Review
- Inter-molecular epitope spreading does not lead to extension of autoimmunity beyond target tissue in autoimmune glomerulonephritis.PloS one · 2018Article
- Plasma from patients with anti-glomerular basement membrane disease could recognize microbial peptides.PloS one · 2017Article
- Basement membranes and autoimmune diseases.Matrix biology : journal of the International Society for Matrix Biology · 2017Review
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5 authors at 3 institutions in 1 country.
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Abstract
Ab-mediated mechanisms have been considered the major causes of glomerulonephritis (GN). However, recent studies suggest that T cells may be more important in mediating GN. To investigate the effects of antigen-specific CD4(+) T cells, we generated Th1 cell lines specific for this antigen from rats that had been immunized with a recombinant form of the glomerular basement membrane (GBM) antigen, Col4alpha3NC1. Upon the transfer of in vitro-activated T cell lines to pertussis toxin-primed, naive syngeneic rats, the recipients developed severe proteinuria/albuminuria, which plateaued after approximately 35 days. Although no IgG binding to GBM or C3 deposition could be detected by immunofluorescence, five out of eleven rats exhibited severe GN, as judged by the formation of characteristic crescent-shaped lesions in the glomeruli, whereas the others exhibited modest GN. Thus Col4alpha3NC1-specific T cells directly initiated glomerular injury in the recipients. One notable difference from GN induced by active immunization was a T cell infiltration in the renal interstitium, which affected some tubules. We therefore injected fluorescence-labeled Col4alpha3NC1-specific into naive rats, and we found that they were enriched 4.5-fold in the kidney cortex relative to nonspecific control T cells 24 hours later. Many of the T cells were located in the Bowman's space and had a flattened shape, suggesting that the primary target for the T cells was in or adjacent to the Bowman's capsule.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.