ArticleThe Journal of clinical investigation2002
Extrarenal effects on the pathogenesis and relapse of idiopathic nephrotic syndrome in Buffalo/Mna rats.
Article in The Journal of clinical investigation, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 71 citations in OpenAlex.
- The podocyte: glomerular sentinel at the crossroads of innate and adaptive immunity.Frontiers in immunology · 2023Review
- Current understanding of the molecular mechanisms of circulating permeability factor in focal segmental glomerulosclerosis.Frontiers in immunology · 2023Review
- Immune-mediated entities of (primary) focal segmental glomerulosclerosis.Cell and tissue research · 2021Review
- Rituximab or plasmapheresis for prevention of recurrent focal segmental glomerulosclerosis after kidney transplantation: A systematic review and meta-analysis.World journal of transplantation · 2021Article
- Renal Diseases Associated with Hematologic Malignancies and Thymoma in the Absence of Renal Monoclonal Immunoglobulin Deposits.Diagnostics (Basel, Switzerland) · 2021Review
- Immunopathogenesis of idiopathic nephrotic syndrome in children: two sides of the coin.World journal of pediatrics : WJP · 2021Review
- Molecular Mechanisms of Proteinuria in Minimal Change Disease.Frontiers in medicine · 2021Review
- Recent advances of animal model of focal segmental glomerulosclerosis.Clinical and experimental nephrology · 2018Review
- Molecular and Cellular Mechanisms for Proteinuria in Minimal Change Disease.Frontiers in medicine · 2018Review
- Extrarenal determinants of kidney filter function.Cell and tissue research · 2017Review
- Minimal change disease and idiopathic FSGS: manifestations of the same disease.Nature reviews. Nephrology · 2016Review
- Update on the treatment of focal segmental glomerulosclerosis in renal transplantation.World journal of transplantation · 2016Review
- FSGS Recurrence in Adults after Renal Transplantation.BioMed research international · 2016Review
- The experimental model of nephrotic syndrome induced by Doxorubicin in rodents: an update.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2015Review
- Administration of recombinant soluble urokinase receptor per se is not sufficient to induce podocyte alterations and proteinuria in mice.Journal of the American Society of Nephrology : JASN · 2014Article
- Is there B cell involvement in a rat model of spontaneous idiopathic nephrotic syndrome treated with LF15-0195?Journal of nephrology · 2014Article
- Circulating angiopoietin-like 4 links proteinuria with hypertriglyceridemia in nephrotic syndrome.Nature medicine · 2014Article
- Animal models of nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2013Review
- Recent progress in the pathophysiology and treatment of FSGS recurrence.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2013Review
- Models of chronic kidney disease.Drug discovery today. Disease models · 2010Article
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Buffalo/Mna rats spontaneously develop a focal segmental glomerulosclerosis with a histological pattern similar to the human disease. In this study, we investigated the potential of recurrence of the disease by transplantation of normal kidneys into Buffalo/Mna recipients. Kidneys from healthy LEW.1W rats were grafted into proteinuric 6-month-old Buffalo/Mna rats without or with specific tolerance induction following donor-specific transfusion (DST) aimed at controlling host anti-donor immune responses. The inverse combination was carried out to determine whether a proteinuric Buffalo/Mna kidney can recover its permselectivity in a normal environment. As a control, LEW.1W kidneys were grafted into Wistar Furth recipients. After transplantation without DST, recurrence of proteinuria in LEW.1W kidneys appeared at approximately 10 days, possibly associated with rejection of the graft. In the same combination with DST, proteinuria occurred after 20 days, and the attendant glomerular damage suggested that the initial kidney disease had recurred. Transplanted control animals remained free of proteinuria. In the opposite combination, the proteinuria and the lesions of Buffalo/Mna kidneys regressed after transplantation into healthy LEW.1W rats. The recurrence of proteinuria after transplantation in Buffalo/Mna and the remission of lesions in Buffalo/Mna kidneys transplanted into normal hosts suggests that Buffalo/Mna rats express circulating albuminuric factors, which may be relevant to the relapse of idiopathic nephrotic syndrome in humans.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.