Evidence map›Paper›PMID 11854260›Full record

ArticleInfection and immunity2002

Discordance between T-cell receptor expression and effector function in mice infected with Histoplasma capsulatum.

George S Deepe, Reta S Gibbons, Susan R Ward

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Characterization of the Histoplasma capsulatum-induced granuloma.Journal of immunology (Baltimore, Md. : 1950) · 2006
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

George S DeepeVeterans Affairs Hospital and Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0560, USA. george.deepe@uc.edu
Reta S Gibbons
Susan R Ward

Funding

T CELL RECEPTOR USAGE IN PULMONARY HISTOPLASMOSISR37AI042747 · NIAID · UNIVERSITY OF CINCINNATI · PI DEEPE, GEORGE S. · 1997 to 2006
$2.2M
NIAID NIH HHS AI-42747NIAID NIH HHS R37 AI042747
6 · The paper itself

Abstract

V beta 10(+) and V beta 14(+) T cells were selectively increased 7 to 14 days following infection in the lungs of naive mice infected with Histoplasma capsulatum. Following secondary challenge of immune mice, V beta 1(+) and V beta 8.1(+) cells were sporadically increased. Elimination of V beta 10(+) and V beta 14(+) cells from naive mice did not alter the course of infection over a period of 21 days. Thus, overexpression of V beta families does not necessarily signify a key role in host defense.

Indexed as

AnimalsGenes, T-Cell Receptor betaHistoplasmosisLung Diseases, FungalMaleMiceMice, Inbred BALB CMice, NudeReceptors, Antigen, T-Cell, alpha-betaSpleenReceptors, Antigen, T-Cell, alpha-beta

Identifiers

PMID11854260
PMCPMC127812

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.