ArticleInfection and immunity2002
Expression of surfactant protein D in the human gastric mucosa and during Helicobacter pylori infection.
Article in Infection and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 59 citations in OpenAlex.
- Budesonide/formoterol enhances the expression of pro Surfactant Protein-B in lungs of COPD patients.PloS one · 2013Trial
- Surfactant protein D: prognostic insights and emerging therapeutic roles in cancer.Frontiers in immunology · 2026Review
- A Narrative Review on the Multifaceted Roles of Galectins in Host-Pathogen Interactions DuringInternational journal of molecular sciences · 2025Review
- Exosome-Mediated Lectin Pathway and Resistin-MIF-AA Metabolism Axis Drive Immune Dysfunction in Immune Thrombocytopenia.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Strategies ofFrontiers in cellular and infection microbiology · 2024Review
- Intravenous surfactant protein D inhibits lipopolysaccharide-induced systemic inflammation.Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft · 2023Article
- Collectins: Innate Immune Pattern Recognition Molecules.Advances in experimental medicine and biology · 2020Review
- Surfactant Protein D in Respiratory and Non-Respiratory Diseases.Frontiers in medicine · 2018Review
- Surfactant protein D is a causal risk factor for COPD: results of Mendelian randomisation.The European respiratory journal · 2017Article
- Galectin-3 Plays an Important Role in Innate Immunity to Gastric Infection by Helicobacter pylori.Infection and immunity · 2016Article
- Implication of antigenic conversion of Helicobacter pylori lipopolysaccharides that involve interaction with surfactant protein D.Infection and immunity · 2012Article
- Novel role for surfactant protein A in gastrointestinal graft-versus-host disease.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Genetic variant associations of human SP-A and SP-D with acute and chronic lung injury.Frontiers in bioscience (Landmark edition) · 2012Review
- Protective role of the lung collectins surfactant protein A and surfactant protein D in airway inflammation.The Journal of allergy and clinical immunology · 2008Article
- C1q- and collectin-dependent phagocytosis of apoptotic host cells by the intestinal protozoan Entamoeba histolytica.The Journal of infectious diseases · 2008Article
- Regulation of surfactant protein D in the rodent prostate.Reproductive biology and endocrinology : RB&E · 2007Article
- Helicobacter pylori persistence: an overview of interactions between H. pylori and host immune defenses.Clinical microbiology reviews · 2006Review
- Variations in Helicobacter pylori lipopolysaccharide to evade the innate immune component surfactant protein D.Infection and immunity · 2005Article
- The role of surfactant protein D in the colonisation of the respiratory tract and onset of bacteraemia during pneumococcal pneumonia.Respiratory research · 2005Article
- Gastric transcription profile of Helicobacter pylori infection in the rhesus macaque.Infection and immunity · 2004Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Helicobacter pylori establishes persistent infection of gastric mucosa with diverse clinical outcomes. The innate immune molecule surfactant protein D (SP-D) binds selectively to microorganisms, inducing aggregation and phagocytosis. In this study, we demonstrated the expression of SP-D in gastric mucosa by reverse transcription-PCR and immunohistochemical analysis. SP-D is present at the luminal surface and within the gastric pits, with maximal expression at the surface. Levels of expression are significantly increased in H. pylori-associated gastritis compared to those in the normal mucosa. Immunofluorescence microscopy was used to demonstrate binding and agglutination of H. pylori by SP-D in a lectin-specific manner. These activities resulted in a 50% reduction in the motility of H. pylori, as judged on the basis of curvilinear velocity measured by using a Hobson BacTracker. Lipopolysaccharides extracted from three H. pylori strains were shown to bind SP-D in a concentration-dependent manner, and there was marked variation in the avidity of binding among the strains. SP-D may therefore play a significant role in the innate immune response to H. pylori infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.