ArticleInfection and immunity2002
Extracellular antigens from Salmonella enteritidis induce effective immune response in mice after oral vaccination.
Article in Infection and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 58 citations in OpenAlex.
- Review
- Diet-induced obese mice exhibit altered immune responses to early Salmonella Typhimurium oral infection.Journal of microbiology (Seoul, Korea) · 2018Article
- Surface engineered polyanhydride-based oralInternational journal of nanomedicine · 2018Article
- Dual Immunization with SseB/Flagellin Provides Enhanced Protection againstJournal of immunology (Baltimore, Md. : 1950) · 2017Article
- U-Omp19 fromFrontiers in immunology · 2017Article
- Immunity to intestinal pathogens: lessons learned from Salmonella.Immunological reviews · 2014Review
- The Subtleties and Contrasts of the LeuO Regulator in Salmonella Typhi: Implications in the Immune Response.Frontiers in immunology · 2014Review
- Identification of a common immune signature in murine and human systemic Salmonellosis.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Salmonella enterica serovar enteritidis core O polysaccharide conjugated to H:g,m flagellin as a candidate vaccine for protection against invasive infection with S. enteritidis.Infection and immunity · 2011Article
- Evaluation of a novel chimeric B cell epitope-based vaccine against mastitis induced by either Streptococcus agalactiae or Staphylococcus aureus in mice.Clinical and vaccine immunology : CVI · 2011Article
- Mucosal vaccines: recent progress in understanding the natural barriers.Pharmaceutical research · 2010Review
- Tracking the dynamics of salmonella specific T cell responses.Current topics in microbiology and immunology · 2009Review
- Influence of promoter, gene copy number, and preexisting immunity on humoral and cellular responses to a vectored antigen delivered by a Salmonella enterica vaccine.Clinical and vaccine immunology : CVI · 2009Article
- Chicken cecum immune response to Salmonella enterica serovars of different levels of invasiveness.Infection and immunity · 2007Article
- Partially assembled K99 fimbriae are required for protection.Infection and immunity · 2005Article
- Review
- Host and bacterial factors affecting induction of immune responses to flagellin expressed by attenuated Salmonella vaccine strains.Infection and immunity · 2004Article
- Protection against systemic candidiasis in mice immunized with secreted aspartic proteinase 2.Immunology · 2004Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have studied polyacryl starch microparticles as an adjuvant in oral vaccination in mice. Secreted antigens from Salmonella enterica serovar Enteritidis were administered covalently conjugated to microparticles, or as free antigens, orally or intramuscularly and evaluated for their immunogenicity and ability to elicit protective immune response against an oral challenge with live serovar Enteritidis. The highest immunoglobulin M (IgM)-plus-IgG titers were obtained in the groups immunized with antigen-conjugated microparticles. The subclass profile switched to a stronger Th1 influence in the oral groups after booster, while the intramuscular group showed a constant Th1/Th2 profile. A strong specific IgA response was seen in feces in the oral groups, which was further confirmed in an enzyme-linked immunospot assay. The delayed-type hypersensitivity test, as a measure of the cellular response, showed a significant increase in ear thickness in all the immunized groups, except for the group that received free antigen orally, compared to the nonimmunized group. The cytokines released from in vitro-stimulated spleens showed a strong gamma interferon response in all immunized groups. A significant reduction in CFU in liver and spleen was seen in the orally immunized groups compared to the nonimmunized group after oral challenge with serovar Enteritidis. Western blotting analysis with both sera and feces revealed that antibodies against three bands, 53, 56, and 60 kDa, dominated the oral groups, and an electrospray-mass spectroscopy analysis of these bands showed amino acid sequences coinciding with those of phase-1 flagellin and hook-associated protein 2.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.