ArticleInfection and immunity2002
Correlation between an in vitro invasion assay and a murine model of Burkholderia cepacia lung infection.
Article in Infection and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 61 citations in OpenAlex.
- Trial
- Host-pathogen interaction: Enterobacter cloacae exerts different adhesion and invasion capacities against different host cell types.PloS one · 2023Article
- Isolation and identification of Pandoraea spp. From bronchoalveolar lavage of cystic fibrosis patients in Iran.Italian journal of pediatrics · 2019Article
- Microbial uptake by the respiratory epithelium: outcomes for host and pathogen.FEMS microbiology reviews · 2019Review
- Immune Recognition of the Epidemic Cystic Fibrosis Pathogen Burkholderia dolosa.Infection and immunity · 2017Article
- AnFrontiers in microbiology · 2017Article
- An Oxygen-Sensing Two-Component System in the Burkholderia cepacia Complex Regulates Biofilm, Intracellular Invasion, and Pathogenicity.PLoS pathogens · 2017Article
- Identification and Characterization of msf, a Novel Virulence Factor in Haemophilus influenzae.PloS one · 2016Article
- Article
- Mechanisms of Disease: Host-Pathogen Interactions between Burkholderia Species and Lung Epithelial Cells.Frontiers in cellular and infection microbiology · 2015Review
- Potential of metabolomics to reveal Burkholderia cepacia complex pathogenesis and antibiotic resistance.Frontiers in microbiology · 2015Review
- In vitro and in vivo cell invasion and systemic spreading of Mycoplasma agalactiae in the sheep infection model.International journal of medical microbiology : IJMM · 2014Article
- Infection of Burkholderia cepacia induces homeostatic responses in the host for their prolonged survival: the microarray perspective.PloS one · 2013Article
- Article
- Profiling of Burkholderia cepacia secretome at mid-logarithmic and early-stationary phases of growth.PloS one · 2011Article
- Cable pili and the associated 22 kDa adhesin contribute to Burkholderia cenocepacia persistence in vivo.PloS one · 2011Article
- Burkholderia cenocepacia creates an intramacrophage replication niche in zebrafish embryos, followed by bacterial dissemination and establishment of systemic infection.Infection and immunity · 2010Article
- Pseudomonas aeruginosa alginate promotes Burkholderia cenocepacia persistence in cystic fibrosis transmembrane conductance regulator knockout mice.Infection and immunity · 2010Article
- Virulence and cellular interactions of Burkholderia multivorans in chronic granulomatous disease.Infection and immunity · 2009Article
- Burkholderia mallei cellular interactions in a respiratory cell model.Journal of medical microbiology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Our understanding of the virulence of Burkholderia cepacia complex lung infections in cystic fibrosis patients is incomplete. There is a great deal of variability in the clinical course, from simple colonization to severe and often fatal necrotizing pneumonia, termed cepacia syndrome. Multiple subspecies (called genomovars) have been identified, and these genomovars may hold the key to understanding the variable pathogenicity. Thirty-one B. cepacia complex isolates belonging to five of the seven genomovars were examined by using a gentamicin protection assay of invasion with A549 cells. The level of epithelial cell invasion by B. cepacia in the A549 model was relatively low compared with the data obtained for other pathogens and was often variable from assay to assay. Thus, a statistical approach was used to determine invasiveness. When this model was used, one of four genomovar I strains (25%), three of eight genomovar II strains (37.5%), seven of nine genomovar III strains (77.8%), one of four genomovar IV strains (25%), and none of the four genomovar V strains examined were defined as invasive. All other strains were categorized as either noninvasive or indeterminate. Invasive, noninvasive, and indeterminate isolates belonging to genomovars II and III were subsequently tested for splenic invasion with the mouse agar bead model. Correlation between the models for six strains was demonstrated. Our results indicate that a statistical model used to determine invasiveness in an in vitro invasion assay can be used to predict in vivo invasiveness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.