ArticleOncogene2002
Downregulating PKC delta provides a PI3K/Akt-independent survival signal that overcomes apoptotic signals generated by c-Src overexpression.
Article in Oncogene, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 44 citations in OpenAlex.
- A non-metabolic function of hexokinase 2 in small cell lung cancer: promotes cancer cell stemness by increasing USP11-mediated CD133 stability.Cancer communications (London, England) · 2022Article
- Reduced Apoptosis by Ethanol and Its Association with PKC-δ and Akt Signaling in Ischemic Stroke.Aging and disease · 2014Article
- Early down-regulation of PKCδ as a pro-survival mechanism in Huntington's disease.Neuromolecular medicine · 2014Article
- In Vitro Differentiation and Expansion of Intrathymic T Cell Progenitors from Human Umbilical Cord Blood-Derived CD34(+) Cells.International journal of stem cells · 2009Article
- Protein kinase C-delta mediates neuronal apoptosis in the retinas of diabetic rats via the Akt signaling pathway.Diabetes · 2008Article
- Phosphorylation of protein kinase Cdelta on distinct tyrosine residues induces sustained activation of Erk1/2 via down-regulation of MKP-1: role in the apoptotic effect of etoposide.The Journal of biological chemistry · 2008Article
- CUB domain-containing protein 1 is a novel regulator of anoikis resistance in lung adenocarcinoma.Molecular and cellular biology · 2007Article
- Use of a novel method to find substrates of protein kinase C delta identifies M2 pyruvate kinase.The international journal of biochemistry & cell biology · 2007Article
- Suppression of cell migration by protein kinase Cdelta.Oncogene · 2005Article
- Article
- Silencing of hdm2 oncogene by siRNA inhibits p53-dependent human breast cancer.Cancer gene therapy · 2004Article
- Role of protein kinase C delta in reactivation of Kaposi's sarcoma-associated herpesvirus.Journal of virology · 2004Article
- Efficient synthesis and photodynamic activity of porphyrin-saccharide conjugates: targeting and incapacitating cancer cells.Biochemistry · 2004Article
- Inhibition of protein kinase C promotes neuronal survival in low potassium through an Akt-dependent pathway.Neurotoxicity research · 2004Article
- Positive feedback of protein kinase C proteolytic activation during apoptosis.The Biochemical journal · 2002Article
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- Article
- Cytotoxity of the trans10,cis12 isomer of conjugated linoleic acid on rat hepatoma and its modulation by other fatty acids, tocopherol, and tocotrienol.In vitro cellular & developmental biology. AnimalArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
3Y1 rat fibroblasts overexpressing the tyrosine kinase c-Src (3Y1(c-Src) cells) become transformed by downregulation of protein kinase C delta (PKC delta). However, when 3Y1(c-Src) cells were subjected to serum withdrawal, they underwent apoptosis via a cytochrome c/caspase 9 pathway. In contrast, neither parental nor v-Src-transformed 3Y1 cells underwent apoptosis when subjected to serum withdrawal. If PKC delta was downregulated, the apoptotic phenotypes induced by serum withdrawal in the 3Y1(c-Src) cells were suppressed. The apparent survival signal generated by PKC delta downregulation was independent of the phosphatidylinositol-3-kinase (PI3K)/Akt survival pathway. Collectively, these data indicate that (1) c-Src overexpression renders cells sensitive to apoptotic stress, and (2) that downregulation of PKC delta provides a novel PI3K/Akt-independent survival signal capable of suppressing apoptotic signals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.