ArticleOncogene2002
Novel estrogen and tamoxifen induced genes identified by SAGE (Serial Analysis of Gene Expression).
Article in Oncogene, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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Who cites it
40 citing papers in PubMed.
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- Decreased expression of prolyl hydroxylase 1 is associated with poor prognosis in colorectal cancers.Journal of cancer research and clinical oncology · 2023Article
- FDXR drives primary and endocrine-resistant tumor cell growth in ER+ breast cancer via CPT1A-mediated fatty acid oxidation.Frontiers in oncology · 2023Article
- Autophagy triggers CTSD (cathepsin D) maturation and localization inside cells to promote apoptosis.Autophagy · 2021Article
- Review
- Hormonal Regulation of Semaphorin 7a in ERCancer research · 2021Article
- Iron chelation and 2-oxoglutarate-dependent dioxygenase inhibition suppress mantle cell lymphoma's cyclin D1.Journal of cellular and molecular medicine · 2019Article
- The role of 17β‑estradiol‑induced upregulation of Piwi‑like 4 in modulating gene expression and motility in breast cancer cells.Oncology reports · 2018Article
- The PHD1 oxygen sensor in health and disease.The Journal of physiology · 2018Review
- EglN2 contributes to triple negative breast tumorigenesis by functioning as a substrate for the FBW7 tumor suppressor.Oncotarget · 2017Article
- New Insights into Protein Hydroxylation and Its Important Role in Human Diseases.Biochimica et biophysica acta · 2016Review
- EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer.The EMBO journal · 2015Article
- Cell cycle progression in response to oxygen levels.Cellular and molecular life sciences : CMLS · 2014Review
- ERα upregulates Phd3 to ameliorate HIF-1 induced fibrosis and inflammation in adipose tissue.Molecular metabolism · 2014Article
- Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase.Genes & development · 2014Article
- Activation of hypoxia-inducible factor-1 in pulmonary arterial smooth muscle cells by endothelin-1.American journal of physiology. Lung cellular and molecular physiology · 2013Article
- Transcriptional activation of breast cancer-associated gene 2 by estrogen receptor.Breast cancer research and treatment · 2012Article
- Expression of prolyl hydroxylases (PHDs) is selectively controlled by HIF-1 and HIF-2 proteins in nucleus pulposus cells of the intervertebral disc: distinct roles of PHD2 and PHD3 proteins in controlling HIF-1α activity in hypoxia.The Journal of biological chemistry · 2012Article
- Hypoxia inducible factor-1: its potential role in cerebral ischemia.Cellular and molecular neurobiology · 2012Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The breast cancer promoting effects of estrogen and the chemopreventive effects of tamoxifen are thought to be mediated by the estrogen receptor, a ligand-dependent transcription factor. Therefore, comprehensive analysis of gene expression profiles following estrogen or tamoxifen treatment may help us better understand the role estrogen plays in tumorigenesis. We utilized SAGE (Serial Analysis of Gene Expression) technology to identify genes regulated by estrogen and tamoxifen in the ZR75-1 estrogen dependent breast cancer cell line. In this manner we have identified several genes that were regulated by estrogen or tamoxifen. Here we report the identification and initial characterization of EIT-6 (Estrogen Induced Tag-6), a novel nuclear protein and a new member of the evolutionarily conserved SM-20 family of growth regulatory immediate-early genes. EIT-6 appears to be a direct transcriptional target of the estrogen receptor and constitutive expression of EIT-6 promotes colony growth in human breast cancer cells. These data indicate that EIT-6 may play a role in estrogen induced cell growth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.