ArticleOncogene2002
Regulation of the mitochondrial checkpoint in p53-mediated apoptosis confers resistance to cell death.
Article in Oncogene, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 65 citations in OpenAlex.
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- Ethylene glycol monomethyl ether-induced testicular oxidative stress and time-dependent up-regulation of apoptotic, pro-inflammatory, and oncogenic markers in rats.Metabolism open · 2020Article
- Induction of intrinsic apoptotic signaling pathway in A549 lung cancer cells using silver nanoparticles fromBiotechnology reports (Amsterdam, Netherlands) · 2019Article
- Effect of baicalin on proliferation and apoptosis in pancreatic cancer cells.American journal of translational research · 2019Article
- Thiamine antagonists trigger p53-dependent apoptosis in differentiated SH-SY5Y cells.Scientific reports · 2017Article
- Chrysin induces cell apoptosis via activation of the p53/Bcl-2/caspase-9 pathway in hepatocellular carcinoma cells.Experimental and therapeutic medicine · 2016Article
- Article
- Dihydromyricetin induces apoptosis and inhibits proliferation in hepatocellular carcinoma cells.Oncology letters · 2014Article
- Elements in the Development of a Production Process for Modified Vaccinia Virus Ankara.Microorganisms · 2013Review
- Resistance and gain-of-resistance phenotypes in cancers harboring wild-type p53.Biochemical pharmacology · 2012Review
- Mitochondrial localization of p53 during adenovirus infection and regulation of its activity by E1B-19K.Oncogene · 2005Article
- Novel rapid tissue lysis method to evaluate cancer proteins: correlation between elevated Bcl-X(L) expression and colorectal cancer cell proliferation.World journal of gastroenterology · 2005Article
- Apoptosis or growth arrest: modulation of the cellular response to p53 by proliferative signals.Oncogene · 2003Article
- To kill or be killed: viral evasion of apoptosis.Nature immunology · 2002Review
- Bak and Bax function to limit adenovirus replication through apoptosis induction.Journal of virology · 2002Article
- Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
The p53 tumor suppressor protein inhibits tumor formation, in part by inducing apoptosis, which is inhibited by anti-apoptotic Bcl-2 family members Bcl-2 and adenovirus E1B 19K. We have identified p53-apoptotic signaling events which are targeted for inhibition by E1B 19K. Apoptotic signaling by p53 induced a Bid-independent conformational change in Bax, a Bax-Bak interaction, release of cytochrome c and Smac/DIABLO from mitochondria, caspase-9 and -3 activation, cleavage of known caspase substrates, and apoptosis. When p53-dependent apoptosis was blocked by E1B 19K expression, E1B 19K bound Bak, and the Bax-Bak interaction was inhibited. Cytochrome c and Smac/DIABLO release from mitochondria was also inhibited in E1B 19K expressing cells and cells remained viable. After a prolonged p53 death stimulus, the inhibition of the mitochondrial death checkpoint by E1B 19K failed, and cytochrome c and Smac/DIABLO were released from mitochondria, and became degraded. Despite this eventual failure to inhibit the mitochondrial checkpoint, caspase-9 and -3 were not activated, and cells remained viable even upon treatment with an exogenous death stimulus. Thus, p53 induces apoptosis in part through Bax and Bak, and even an incomplete inhibition of this mitochondrial checkpoint may be sufficient to confer resistance to cell death.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.