ReviewOncogene2002
Analysis of telomerase as a diagnostic biomarker of cervical dysplasia and carcinoma.
Review in Oncogene, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 53 citations in OpenAlex.
- From HPV infection to cervical precancer: Molecular mechanisms, immune microenvironment and emerging technologies.Cellular and molecular life sciences : CMLS · 2026Review
- Concomitant underexpression of TGFBR2 and overexpression of hTERT are associated with poor prognosis in cervical cancer.Scientific reports · 2017Article
- The status of telomerase enzyme activity in benign and malignant gynaecologic pathologies.Balkan medical journal · 2013Article
- Immunosuppressive tumor microenvironment in cervical cancer patients.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2011Article
- Immunohistochemical expression of ubiquitin and telomerase in cervical cancer.Virchows Archiv : an international journal of pathology · 2009Article
- Telomerase activity as a tumor marker in Indian women with cervical intraepithelial neoplasia and cervical cancer.Molecular diagnosis & therapy · 2007Article
- Potential of telomerase expression and activity in cervical specimens as a diagnostic tool.Journal of clinical pathology · 2005Article
- Telomerase activity as a potential diagnostic marker for triage of abnormal Pap smears.Journal of lower genital tract disease · 2005Article
- Telomere attrition predominantly occurs in precursor lesions during in vivo carcinogenic process of the uterine cervix.Oncogene · 2004Article
- Chromosome in situ hybridisation, Ki-67, and telomerase immunocytochemistry in liquid based cervical cytology.Journal of clinical pathology · 2004Article
- Telomerase detection in the diagnosis and prognosis of cancer.Cytotechnology · 2004Article
- Detection of genomic amplification of the human telomerase gene (TERC) in cytologic specimens as a genetic test for the diagnosis of cervical dysplasia.The American journal of pathology · 2003Article
- Transcriptomic Network Analysis Using Exfoliative Cervical Cells Could Discriminate a Potential Risk of Progression to Cancer in HPV-related Cervical Lesions: A Pilot Study.Cancer genomics & proteomicsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Telomerase expression is a potentially important marker of high-grade cervical dysplasia and squamous cell carcinoma (SCC). The routine practice of cervical cytology is limited by problems of false negative diagnoses as well as by poor specificity for clinically significant lesions in patients with low-grade cytologic abnormalities. Telomerase is widely expressed in most SCCs as well as in a high proportion of high-grade squamous intraepithelial lesions. Histochemical studies have confirmed that telomerase is expressed in the lower portions of normal or metaplastic squamous mucosa but that telomerase positive cells extend into the upper epithelial layers in cases of high-grade dysplasia. Since the cervical smear samples the uppermost cell layers of the cervical mucosa, but does not normally include cells derived from the lower layers of the squamous mucosa, the detection of telomerase in exfoliated cells of the cervical smear may have specificity for clinically significant lesions. The analysis of hTR, hTERT, and telomerase activity are complicated by a number of technical factors that may lead to either false negative or false positive test results. Thus, the practical application of telomerase analysis as a diagnostic adjunct for cervical cytopathology may depend on the development of more reliable and sensitive assay systems, possibly formatted for cytochemical applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.