ReviewOncogene2002
Telomerase: its clinical relevance in the diagnosis of bladder cancer.
Review in Oncogene, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 57 citations in OpenAlex.
- Activating TelomeraseInternational journal of molecular sciences · 2020Review
- Pathobiology and chemoprevention of bladder cancer.Journal of oncology · 2011Article
- Expression and biological-clinical significance of hTR, hTERT and CKS2 in washing fluids of patients with bladder cancer.BMC urology · 2010Article
- CK20 and Ki-67 as significant prognostic factors in human bladder carcinoma.Clinical and experimental medicine · 2010Article
- Down-regulation of TERE1/UBIAD1 activated Ras-MAPK signalling and induced cell proliferation.Cell biology international reports · 2010Article
- The current role of telomerase in the diagnosis of bladder cancer.Indian journal of urology : IJU : journal of the Urological Society of India · 2009Article
- Genes involved in differentiation, stem cell renewal, and tumorigenesis are modulated in telomerase-immortalized human urothelial cells.Molecular cancer research : MCR · 2008Article
- [Molecular diagnostics in urologic oncology. Detection of nucleic acids in urine samples].Der Urologe. Ausg. A · 2003Review
- Urine telomerase: an important marker in the diagnosis of bladder cancer.Neoplasia (New York, N.Y.)Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
More than 50 years ago, Papanicolaou recognized the importance of a non-invasive technique for the diagnosis and follow-up of patients with carcinoma of the urinary bladder. Cystoscopy, however, has remained the 'gold standard' since no currently available non-invasive method can compete with cystoscopy's sensitivity and specificity. The detection of the ribonucleoprotein telomerase or the telomerase subunits human telomerase RNA (hTR) and human telomerase reverse transcriptase (hTERT) in urine samples offer new diagnostic perspectives. The present article presents a review of publications in the literature and evaluates their clinical relevance. The experimental studies reported to date are very promising and show that telomerase exactly fulfils the requirements for a good diagnostic marker for carcinoma of the urinary bladder. The diagnostic application remains in an experimental stage and telomerase is still several steps away for routine use as a clinical parameter. The remaining steps leading to its routine clinical application will be discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.