ArticleThe Journal of physiology2002
Group II metabotropic glutamate receptor activation is required for normal hippocampal mossy fibre development in the rat.
Article in The Journal of physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 28 citations in OpenAlex.
- Metabotropic Glutamate Receptors in Alzheimer's Disease Synaptic Dysfunction: Therapeutic Opportunities and Hope for the Future.Journal of Alzheimer's disease : JAD · 2020Review
- The Molecular and Cellular Mechanisms of Axon Guidance in Mossy Fiber Sprouting.Frontiers in neurology · 2018Review
- Developmental decline in modulation of glutamatergic synapses in layer IV of the barrel cortex by group II metabotropic glutamate receptors.Neuroscience · 2015Article
- Differential expression of mGluR2 in the developing cerebral cortex of the mouse.Journal of biomedical science and engineering · 2014Article
- Two-photon imaging of Zn2+ dynamics in mossy fiber boutons of adult hippocampal slices.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Influence of brain-derived neurotrophic factor on pathfinding of dentate granule cell axons, the hippocampal mossy fibers.Molecular brain · 2009Article
- Long-range axonal calcium sweep induces axon retraction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- GABAergic signaling at mossy fiber synapses in neonatal rat hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Mossy fiber pathfinding in multilayer organotypic cultures of rat hippocampal slices.Cellular and molecular neurobiology · 2003Article
- Calcineurin plays different roles in group II metabotropic glutamate receptor- and NMDA receptor-dependent long-term depression.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glutamate is the main neurotransmitter at hippocampal mossy fibre (MF) terminals. Because neurotransmitters have been proposed as regulating factors of neural network formation and neurite morphogenesis in the developing CNS, we examined the possible contribution of glutamate to MF pathfinding. Entorhino-hippocampal slices prepared from early postnatal rats were cultivated in the presence of glutamate receptor antagonists. Timm histochemical staining revealed that pharmacological blockade of metabotropic glutamate receptors (mGluR), but not of ionotropic glutamate receptors, induced abnormal outgrowth of the MFs. When slices were cultured in the presence of mGluR antagonists, DiI-labelled MF axons displayed a great degree of defasciculation, and MF-mediated EPSPs in the CA3 pyramidal cells were altered. Similar results were obtained for a selective antagonist of group II mGluR, but not of group I or III mGluR. Glutamate is, therefore, likely to regulate MF outgrowth via activation of group II mGluR. The present study may provide a novel role of glutamate in hippocampal development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.