ArticleThe Journal of physiology2002
Role of ATP decrease in secretion induced by mitochondrial dysfunction in guinea-pig adrenal chromaffin cells.
Article in The Journal of physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 29 citations in OpenAlex.
- Expression and function of mitochondrial inhibitor factor-1 and TASK channels in adrenal cells.Biochemical and biophysical research communications · 2023Article
- Neuronal control of astrocytic respiration through a variant of the Crabtree effect.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Article
- Calcium and adenosine triphosphate control of cellular pathology: asparaginase-induced pancreatitis elicited via protease-activated receptor 2.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Article
- Bile acids inhibit Na⁺/H⁺ exchanger and Cl⁻/HCO₃⁻ exchanger activities via cellular energy breakdown and Ca²⁺ overload in human colonic crypts.Pflugers Archiv : European journal of physiology · 2015Article
- Selective ion changes during spontaneous mitochondrial transients in intact astrocytes.PloS one · 2011Article
- Plasma membrane calcium pump regulation by metabolic stress.World journal of biological chemistry · 2010Article
- Oxidant-induced inhibition of the plasma membrane Ca2+-ATPase in pancreatic acinar cells: role of the mitochondria.American journal of physiology. Cell physiology · 2008Article
- Subunit composition and role of Na+,K+-ATPases in adrenal chromaffin cells.The Journal of physiology · 2005Article
- The effect of mitochondrial inhibitors on membrane currents in isolated neonatal rat carotid body type I cells.The Journal of physiology · 2004Article
- GABA uptake into astrocytes is not associated with significant metabolic cost: implications for brain imaging of inhibitory transmission.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Rotenone selectively occludes sensitivity to hypoxia in rat carotid body glomus cells.The Journal of physiology · 2003Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanism related to mitochondrial dysfunction-induced catecholamine (CA) secretion in dispersed guinea-pig adrenal chromaffin cells was investigated using amperometry and confocal laser microscopy. Application of CCCP, which does not stimulate generation of reactive oxygen species (ROS), reversibly induced CA secretion, whereas application of either cyanide or oligomycin (OL), a stimulator for ROS, enhanced CA secretion to a smaller extent. The CCCP-induced secretion was abolished by removal of external Ca2+ ions and was markedly diminished by D600. The mitochondrial membrane potential, measured using rhodamine 123, was rapidly lost in response to CCCP, but did not change noticeably during a 3 min exposure to OL. Prior exposure to OL markedly facilitated depolarization of the mitochondrial membrane potential in response to cyanide. The mitochondrial inhibitors rapidly produced an increase in Magnesium Green (MgG) fluorescence in the absence of external Ca2+ and Mg2+ ions, an increase that was larger in the cytoplasm than in the nucleus. The rank order of potency in increasing MgG fluorescence among the inhibitors was similar to that in increasing secretion. Thus, mitochondrial inhibition rapidly decreases [ATP] and the mitochondrial dysfunction-induced secretion is not due to ROS generation or to mitochondrial depolarization, but is possibly mediated by a decrease in ATP.
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