ArticleThe Journal of physiology2002
Phasic and tonic attenuation of EPSPs by inward rectifier K+ channels in rat hippocampal pyramidal cells.
Article in The Journal of physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 79 citations in OpenAlex.
- Heavy adolescent drinking makes the adult brain more vulnerable to ethanol by permanently altering the age-dependent interplay between alcohol, GIRK channels and activin.Molecular psychiatry · 2026Article
- Single Prolonged Stress Reduces Intrinsic Excitability and Excitatory Synaptic Drive Onto Pyramidal Neurons in the Infralimbic Prefrontal Cortex of Adult Male Rats.Frontiers in cellular neuroscience · 2021Article
- Postsynaptic integrative properties of dorsal CA1 pyramidal neuron subpopulations.Journal of neurophysiology · 2020Article
- Prolonged seizure activity causes caspase dependent cleavage and dysfunction of G-protein activated inwardly rectifying potassium channels.Scientific reports · 2017Article
- Adenosine Differentially Modulates Synaptic Transmission of Excitatory and Inhibitory Microcircuits in Layer 4 of Rat Barrel Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Neuronal Chloride Regulation via KCC2 Is Modulated through a GABAThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- The Role of cGMP on Adenosine A 1 Receptor-mediated Inhibition of Synaptic Transmission at the Hippocampus.Frontiers in pharmacology · 2016Article
- Postsynaptic adenosine A2A receptors modulate intrinsic excitability of pyramidal cells in the rat basolateral amygdala.The international journal of neuropsychopharmacology · 2015Article
- Modulation of synaptic transmission by adenosine in layer 2/3 of the rat visual cortex in vitro.Neuroscience · 2014Article
- Presynaptic adenosine A₁ receptors modulate excitatory transmission in the rat basolateral amygdala.Neuropharmacology · 2014Article
- Glial adenosine kinase--a neuropathological marker of the epileptic brain.Neurochemistry international · 2013Review
- The imbalanced expression of adenosine receptors in an epilepsy model corrected using targeted mesenchymal stem cell transplantation.Molecular neurobiology · 2013Article
- Inward-rectifying potassium (Kir) channels regulate pacemaker activity in spinal nociceptive circuits during early life.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Transcriptional expression of voltage-gated Na⁺ and voltage-independent K⁺ channels in the developing rat superficial dorsal horn.Neuroscience · 2013Article
- Article
- IRK-1 potassium channels mediate peptidergic inhibition of Caenorhabditis elegans serotonin neurons via a G(o) signaling pathway.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- 5-hydroxytryptamine 2C receptors tonically augment synaptic currents in the nucleus tractus solitarii.Journal of neurophysiology · 2012Article
- Adenosine release during seizures attenuates GABAA receptor-mediated depolarization.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Baclofen and adenosine inhibition of synaptic transmission at CA3-CA1 synapses display differential sensitivity to K+ channel blockade.Cellular and molecular neurobiology · 2011Article
- An essential role for adenosine signaling in alcohol abuse.Current drug abuse reviews · 2010Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We made whole-cell recordings from CA1 pyramidal cells of hippocampal slices in combination with brief dendritic glutamate pulses to study the role of constitutive inwardly rectifying K+ channels (IRK, Kir2.0) and G-protein-activated inwardly rectifying K+ channels (GIRK, Kir3.0) in the processing of excitatory inputs. Phasic activation of GIRK channels by baclofen (20 microM) produced a reversible reduction of glutamate-evoked postsynaptic potentials (GPSPs), our equivalent of EPSPs, by about one-third. Conversely, tertiapin (30 nM), a selective inhibitor of GIRK channels, and Ba2+ (200 microM), a non-selective blocker of inwardly rectifying K+ channels, enhanced GPSPs and, in voltage-clamp experiments, reduced the underlying K+ conductances, indicating a functionally significant background GIRK conductance, in addition to constitutive IRK channel activity. When examined after suppression of endogenous adenosinergic inhibition, using either adenosine deaminase or the selective A1 receptor antagonist, 1,3-dipropyl-8-cyclopentylxanthine, tertiapin failed to influence either the GPSPs or the inwardly rectifying K+ conductance. Voltage-clamp recordings from acutely isolated CA1 pyramidal cells not exposed to ambient adenosine exhibited no response to tertiapin, whereas Ba2+ was still capable of reducing hyperpolarizing inward rectification. Our data indicate that in hippocampal pyramidal cells, two components of the inwardly rectifying K+ conductance can be identified, which together exert a tonic modulation of excitatory synaptic input: one arises from constitutive putative IRK channels, the other is mediated by the background activity of GIRK channels that results from the tonic activation of A1 receptors by ambient adenosine.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.