ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Activation of central terminal vanilloid receptor-1 receptors and alpha beta-methylene-ATP-sensitive P2X receptors reveals a converged synaptic activity onto the deep dorsal horn neurons of the spinal cord.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The trial behind it
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Who cites it
38 citing papers in PubMed, 97 citations in OpenAlex.
- The Circadian Clocks, Oscillations of Pain-Related Mediators, and Pain.Cellular and molecular neurobiology · 2023Review
- Presynaptic inhibition of transient receptor potential vanilloid type 1 (TRPV1) receptors by noradrenaline in nociceptive neurons.The Journal of physiology · 2017Article
- Postnatal Excitability Development and Innervation by Functional Transient Receptor Potential Vanilloid 1 (TRPV1) Terminals in Neurons of the Rat Spinal Sacral Dorsal Commissural Nucleus: an Electrophysiological Study.Molecular neurobiology · 2016Article
- TRPV1-mediated presynaptic transmission in basolateral amygdala contributes to visceral hypersensitivity in adult rats with neonatal maternal deprivation.Scientific reports · 2016Article
- TRPs and pain.Seminars in immunopathology · 2016Review
- Dopamine modulation of transient receptor potential vanilloid type 1 (TRPV1) receptor in dorsal root ganglia neurons.The Journal of physiology · 2016Article
- Article
- Emerging Role of Spinal Cord TRPV1 in Pain Exacerbation.Neural plasticity · 2016Review
- In vivo patch-clamp analysis of the antinociceptive actions of TRPA1 activation in the spinal dorsal horn.Molecular pain · 2015Article
- Transient receptor potential channels as targets for phytochemicals.ACS chemical neuroscience · 2014Review
- Article
- TRP channels and analgesia.Life sciences · 2013Review
- Activation characteristics of transient receptor potential ankyrin 1 and its role in nociception.American journal of physiology. Cell physiology · 2011Article
- The nociceptive and anti-nociceptive effects of bee venom injection and therapy: a double-edged sword.Progress in neurobiology · 2010Review
- Spinal nerve ligation in mouse upregulates TRPV1 heat function in injured IB4-positive nociceptors.The journal of pain · 2010Article
- Endogenous purinergic control of bladder activity via presynaptic P2X3 and P2X2/3 receptors in the spinal cord.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Selective targeting of TRPV1 expressing sensory nerve terminals in the spinal cord for long lasting analgesia.PloS one · 2009Article
- Primary afferents with TRPM8 and TRPA1 profiles target distinct subpopulations of rat superficial dorsal horn neurones.British journal of pharmacology · 2009Article
- Modulation of transient receptor potential Vanilloid 4-mediated membrane currents and synaptic transmission by protein kinase C.Molecular pain · 2009Article
- Purinergic P2X receptors facilitate inhibitory GABAergic and glycinergic neurotransmission to cardiac vagal neurons in the nucleus ambiguus.Brain research · 2008Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Using a spinal cord slice preparation and patch-clamp recordings from spinal cord dorsal horn neurons, we examined excitatory and inhibitory circuits connecting to lamina V neurons after the activation of afferent central terminal vanilloid receptor-1 (VR1) receptors and P2X receptors. We found that single neurons in lamina V often received excitatory inputs from two chemically defined afferent pathways. One of these pathways was polysynaptic from capsaicin-sensitive afferent terminals. In this pathway the capsaicin-sensitive afferent input first activated interneurons in superficial laminas, and then the excitatory activity was transmitted onto lamina V neurons. The second excitatory input was monosynaptic from alpha(beta)m-ATP-sensitive/capsaicin-insensitive afferent terminals. Both capsaicin-sensitive and alpha(beta)m-ATP-sensitive/capsaicin-insensitive pathways also recruited polysynaptic inhibitory inputs to lamina V neurons. Furthermore, we demonstrated that simultaneous activation of both capsaicin-sensitive afferent pathways and alpha(beta)m-ATP-sensitive/capsaicin-insensitive pathways could generate a temporal summation of excitatory inputs onto single lamina V neurons. These convergent pathways may provide a mechanism of sensory integration for two chemically defined sensory inputs and may have implications in different sensory states.
Indexed as
Identifiers
11850450PMC6757570W1912302639What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.