ArticleImmunology2002
Rapid changes in the lymphopoietic and granulopoietic compartments of the marrow caused by stress levels of corticosterone.
Article in Immunology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 64 citations in OpenAlex.
- Defects in B-lymphopoiesis and B-cell maturation underlie prolonged B-cell depletion in ANCA-associated vasculitis.Annals of the rheumatic diseases · 2024Article
- Cage-Free Pullets Minimally Affected by Stocking Density Stressors.Animals : an open access journal from MDPI · 2024Article
- Anti-Inflammatory Activity of a Cyclic Tetrapeptide in Mouse and Human Experimental Models.Pharmaceutics · 2020Article
- Zinc Finger Protein 521 Regulates Early Hematopoiesis through Cell-Extrinsic Mechanisms in the Bone Marrow Microenvironment.Molecular and cellular biology · 2018Article
- Adrenergic and glucocorticoid receptor antagonists reduce ozone-induced lung injury and inflammation.Toxicology and applied pharmacology · 2018Article
- Immune System Dysregulation During Spaceflight: Potential Countermeasures for Deep Space Exploration Missions.Frontiers in immunology · 2018Review
- Activation of the hypothalamic-pituitary-adrenal (HPA) axis contributes to the immunosuppression of mice infected with Angiostrongylus cantonensis.Journal of neuroinflammation · 2016Article
- Stress, cortisol, and B lymphocytes: a novel approach to understanding academic stress and immune function.Stress (Amsterdam, Netherlands) · 2016Article
- Article
- Homologous lactoferrin triggers mobilization of the myelocytic lineage of bone marrow in experimental mice.Stem cells and development · 2013Article
- Biobehavioral influences on recovery following hematopoietic stem cell transplantation.Brain, behavior, and immunity · 2013Review
- Article
- Chronic restraint stress upregulates erythropoiesis through glucocorticoid stimulation.PloS one · 2013Article
- Enhanced production of early lineages of monocytic and granulocytic cells in mice with colitis.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Molecular pathways: beta-adrenergic signaling in cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2012Review
- Depletion and recovery of lymphoid subsets following morphine administration.British journal of pharmacology · 2011Article
- Nutritionally mediated programming of the developing immune system.Advances in nutrition (Bethesda, Md.) · 2011Review
- Role of central leptin signaling in the starvation-induced alteration of B-cell development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Article
- Natural glucocorticoids induce expansion of all developmental stages of murine bone marrow granulocytes without inhibiting function.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Exposure to concentrations of glucocorticoids analogous to those produced during stress, trauma and malnutrition had rapid but varying effects on the major classes of cells within the marrow. Corticosterone (CS) was given as a subdermal implant in young mice and generated 60-95 microg CS/dl of blood compared to 5-15 microg CS/dl for sham controls over a period of 36 hr. Within 24 hr CS had caused losses of 30-70% among the early pro-B, pre-B and immature B cells. The pre-B cells were virtually eliminated by 36 hr and the capacity of surviving pro- and pre-B cells to cycle was reduced by 70-80%. Interestingly, the earliest of B cells, the prepro-B cells, showed considerable resistance to CS, being reduced by only 20% at 36 hr. Thus, the pattern of survival within the B-cell compartment paralleled the expression of Bcl-2. At the 36-hr time-point there were no changes in the proportion of progenitor cells, erythroid or monocytic cells, or number of nucleated cells in the marrow. By contrast, 36 hr after exposure to CS there was an increase of 30% in the proportion and absolute number of cells in the granulocytic compartment. Chronic production of CS appears to reprogramme lymphopoiesis and myelopoiesis, perhaps to preserve the first line of immune defence at the expense of the lymphoid branch. Resistance to apoptosis and modifications in the activity of the glucocorticoid receptor and cytokines produced by stromal cells are postulated as targets for CS-driven changes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.