ArticleJournal of neurovirology2002
Lack of nitric oxide synthase type 2 (NOS2) results in reduced neuronal apoptosis and mortality following mouse hepatitis virus infection of the central nervous system.
Article in Journal of neurovirology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Inducible nitric oxide synthase deficiency promotes murine-β-coronavirus induced demyelination.Virology journal · 2023Article
- Viral mouse models used to study multiple sclerosis: past and present.Archives of virology · 2021Review
- Potential neurological impact of coronaviruses: implications for the novel SARS-CoV-2.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Review
- Virus infection, antiviral immunity, and autoimmunity.Immunological reviews · 2013Review
- CXCR2 signaling and host defense following coronavirus-induced encephalomyelitis.Future virology · 2012Article
- Tempol ameliorates murine viral encephalomyelitis by preserving the blood-brain barrier, reducing viral load, and lessening inflammation.Free radical biology & medicine · 2010Article
- Mouse hepatitis virus infection of the CNS: a model for defense, disease, and repair.Frontiers in bioscience : a journal and virtual library · 2008Article
- Exacerbated pathology of viral encephalitis in mice with central nervous system-specific autoantibodies.The American journal of pathology · 2007Article
- Human coronavirus OC43 infection induces chronic encephalitis leading to disabilities in BALB/C mice.Virology · 2006Article
- Coronavirus infection of the central nervous system: host-virus stand-off.Nature reviews. Microbiology · 2006Review
- HCoV-OC43-induced apoptosis of murine neuronal cells.Advances in experimental medicine and biology · 2006Article
- Reovirus infection of the CNS enhances iNOS expression in areas of virus-induced injury.Experimental neurology · 2005Article
- Neurovirological methods and their applications.Journal of neurology, neurosurgery, and psychiatry · 2003Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The role of nitric oxide synthase type-2 (NOS2)-derived nitric oxide (NO) in the pathogenesis of mouse hepatitis virus (MHV)-induced central nervous system disease was examined. Infection of NOS2 knockout ((-/-)) and NOS2(+/+) mice with MHV resulted in similar kinetics of viral clearance from the brain and comparable levels of demyelination. MHV-infected NOS2(-/-) mice displayed a marked decrease in mortality as compared to infected NOS2(+/+) mice that correlated with a significant decrease (P < or = 0.001) in the number of apoptotic cells (determined by TUNEL staining) present in the brain. Confocal microscopy revealed that the majority of cells (>70%) undergoing apoptosis were neurons. These studies indicate that NOS2-generated NO contributes to apoptosis of neurons but not demyelination following MHV infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.