Trial reportHeart (British Cardiac Society)2002
Impact of angiotensin converting enzyme inhibition on post-coronary artery bypass interleukin 6 release.
Trial report in Heart (British Cardiac Society), 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 90 citations in OpenAlex.
- The Protective Mechanism of Dexmedetomidine on Renal in Hemorrhagic Shock.Computational and mathematical methods in medicine · 2022Trial
- Comparative effects of angiotensin receptor blockade and ACE inhibition on the fibrinolytic and inflammatory responses to cardiopulmonary bypass.Clinical pharmacology and therapeutics · 2012Trial
- Angiotensin-converting enzyme inhibition alters the inflammatory and fibrinolytic response to cardiopulmonary bypass in children.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2011Trial
- Inflammatory Trajectory of Type 2 Diabetes: Novel Opportunities for Early and Late Treatment.Cells · 2024Review
- Guideline-Optimised Treatment in Heart Failure-Do Higher Doses Reduce Systemic Inflammation More Significantly?Journal of clinical medicine · 2024Article
- Puerarin pre-conditioning on the expression levels of CK-MB, cTnI and inflammatory factors in patients undergoing cardiac valve replacement.Experimental and therapeutic medicine · 2019Article
- Immunologic Effects of the Renin-Angiotensin System.Journal of the American Society of Nephrology : JASN · 2017Review
- Association of inflammatory cytokines with mortality in peritoneal dialysis patients.BioMedicine · 2017Article
- Pharmacological strategies for prevention of postoperative atrial fibrillation.Expert review of clinical pharmacology · 2015Review
- Acute Systemic Inflammation is Unlikely to Affect Adiponectin and Leptin Synthesis in Humans.Frontiers in cardiovascular medicine · 2015Article
- Role of ACE I/D gene polymorphisms on the effect of ramipril in inflammatory response and myocardial injury in patients undergoing coronary artery bypass grafts.European journal of clinical pharmacology · 2014Article
- Effects of 60 minutes of hyperoxia followed by normoxia before coronary artery bypass grafting on the inflammatory response profile and myocardial injury.Journal of negative results in biomedicine · 2012Article
- Article
- Validated treatments and therapeutics prospectives regarding pharmacological products for sarcopenia.The journal of nutrition, health & aging · 2009Review
- Reduction of C-reactive protein and the use of anti-hypertensives.Vascular health and risk management · 2007Review
- [Expression of angiotensin I converting enzyme in pulmonary hypertension].Der Pathologe · 2006Article
- C reactive protein concentration and recurrence of atrial fibrillation after electrical cardioversion.Heart (British Cardiac Society) · 2005Article
- Angiotensin converting enzyme gene polymorphism and cardiovascular morbidity and mortality: the Rotterdam Study.Journal of medical genetics · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAngiotensin 1 converting enzyme (ACE) inhibitors reduce morbidity and mortality after coronary artery bypass graft surgery (CABG). This benefit may result from an anti-inflammatory action.
objectiveTo examine the effect of ACE inhibition on interleukin 6 (IL-6) concentrations after CABG. PATIENTS AND
methods161 patients undergoing elective first time CABG were recruited, of whom 41 (25%) were receiving ACE inhibitor treatment; 21 patients with confounding postoperative complications were excluded. After these exclusions there were 33 patients (24%) on ACE inhibitor treatment. Plasma IL-6 was measured preoperatively and again six hours after CABG.
resultsBaseline IL-6 concentrations (geometric mean (SEM)) were non-significantly lower among the patients receiving ACE inhibitors (3.7 (0.1) v 4.3 (0.1) pg/ml, p = 0.12). Overall, post-CABG IL-6 concentrations increased significantly (mean rise 177 (12) pg/ml, p < 0.0005). This response was blunted among ACE inhibitor treated patients. Median increases in IL-6 concentrations were 117 v 193 pg/ml, for treated v non-treated patients, respectively (Kruskal-Wallis, p = 0.02), with peak postoperative IL-6 concentrations lower among the subjects receiving ACE inhibitors than in untreated subjects (142 (19) v 196 (13) pg/ml, p = 0.02). The effect of ACE inhibitors remained significant after multivariate analysis (p = 0.018).
conclusionsACE inhibitor treatment is associated with a reduction in IL-6 response to CABG. The data suggest that this class of drug may have a direct anti-inflammatory effect, which could explain some of its clinical benefit.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.