ArticleThe EMBO journal2002
Conserved properties of hydrogenosomal and mitochondrial ADP/ATP carriers: a common origin for both organelles.
Article in The EMBO journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 106 citations in OpenAlex.
- Environmental Adaptation Strategies of Deep-Sea Fungi.Journal of fungi (Basel, Switzerland) · 2026Review
- Selective loss of ATP carriers in favour of SLC25A43 orthologues in metamonad mitochondria adapted to anaerobiosis.Open biology · 2025Article
- The free-living flagellate Paratrimastix pyriformis uses a distinct mitochondrial carrier to balance adenine nucleotide pools.Archives of biochemistry and biophysics · 2023Article
- Isolation and Biochemical Characterization of Six Anaerobic Fungal Strains from Zoo Animal Feces.Microorganisms · 2021Article
- Sequence Features of Mitochondrial Transporter Protein Families.Biomolecules · 2020Review
- On the Detection and Functional Significance of the Protein-Protein Interactions of Mitochondrial Transport Proteins.Biomolecules · 2020Review
- Heterologous transporters from anaerobic fungi bolster fluoride tolerance inMetabolic engineering communications · 2019Article
- Mapping the membrane proteome of anaerobic gut fungi identifies a wealth of carbohydrate binding proteins and transporters.Microbial cell factories · 2016Article
- Conservation of Transit Peptide-Independent Protein Import into the Mitochondrial and Hydrogenosomal Matrix.Genome biology and evolution · 2015Article
- Transport proteins of parasitic protists and their role in nutrient salvage.Frontiers in plant science · 2014Review
- Biochemistry and evolution of anaerobic energy metabolism in eukaryotes.Microbiology and molecular biology reviews : MMBR · 2012Review
- The plant mitochondrial carrier family: functional and evolutionary aspects.Frontiers in plant science · 2012Article
- Adenine nucleotide transporters in organelles: novel genes and functions.Cellular and molecular life sciences : CMLS · 2011Review
- The core components of organelle biogenesis and membrane transport in the hydrogenosomes of Trichomonas vaginalis.PloS one · 2011Article
- Diversity and reductive evolution of mitochondria among microbial eukaryotes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Review
- Mitochondrion-related organelles in eukaryotic protists.Annual review of microbiology · 2010Review
- Protein import into hydrogenosomes of Trichomonas vaginalis involves both N-terminal and internal targeting signals: a case study of thioredoxin reductases.Eukaryotic cell · 2008Article
- Organelles in Blastocystis that blur the distinction between mitochondria and hydrogenosomes.Current biology : CB · 2008Article
- Genetic evidence for a mitochondriate ancestry in the 'amitochondriate' flagellate Trimastix pyriformis.PloS one · 2008Article
- The yeast mitochondrial ADP/ATP carrier functions as a monomer in mitochondrial membranes.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Mitochondria are one of the hallmarks of eukaryotic cells, exporting ATP in exchange for cytosolic ADP using ADP/ATP carriers (AAC) located in the inner mitochondrial membrane. In contrast, several evolutionarily important anaerobic eukaryotes lack mitochondria but contain hydrogenosomes, peculiar organelles of controversial ancestry that also supply ATP but, like some fermentative bacteria, make molecular hydrogen in the process. We have now identified genes from two species of the hydrogenosome-containing fungus Neocallimastix that have three-fold sequence repeats and signature motifs that, along with phylogenetic analysis, identify them as AACs. When expressed in a mitochondrial AAC- deficient yeast strain, the hydrogenosomal protein was correctly targeted to the yeast mitochondria inner membrane and yielded mitochondria able to perform ADP/ATP exchange. Characteristic inhibitors of mitochondrial AACs blocked adenine nucleotide exchange by the Neocallimastix protein. Thus, our data demonstrate that fungal hydrogenosomes and yeast mitochondria use the same pathway for ADP/ATP exchange. These experiments provide some of the strongest evidence yet that yeast mitochondria and Neocallimastix hydrogenosomes are but two manifestations of the same fundamental organelle.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.