ArticleInternational journal of experimental pathology2001
TNF-alpha is expressed at sites of parasite and tissue destruction in the spleen of mice acutely infected with Trypanosoma cruzi.
Article in International journal of experimental pathology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- The Functions of Cytokines in the Cardiac Immunopathogenesis of Chagas Disease.Pathogens (Basel, Switzerland) · 2024Review
- Article
- In vitro model of postoncosphere development, and in vivo infection abilities of Taenia solium and Taenia saginata.PLoS neglected tropical diseases · 2019Article
- Renovascular hypertension increases serum TNF and CX3CL1 in experimental Trypanosoma cruzi infection.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2018Article
- Domestic Pig (Sus scrofa) as an Animal Model for Experimental Trypanosoma cruzi Infection.The American journal of tropical medicine and hygiene · 2016Article
- Exacerbated skeletal muscle inflammation and calcification in the acute phase of infection by Mexican Trypanosoma cruzi DTUI strain.BioMed research international · 2014Article
- In situ expression of regulatory cytokines by heart inflammatory cells in Chagas' disease patients with heart failure.Clinical & developmental immunology · 2012Article
- Different infective forms trigger distinct immune response in experimental Chagas disease.PloS one · 2012Article
- Retracing micro-epidemics of Chagas disease using epicenter regression.PLoS computational biology · 2011Article
- Combined treatment of heterocyclic analogues and benznidazole upon Trypanosoma cruzi in vivo.PloS one · 2011Article
- Role of NO synthase in the development of Trypanosoma cruzi-induced cardiomyopathy in mice.The American journal of tropical medicine and hygiene · 2009Article
- Increased association of Trypanosoma cruzi with sialoadhesin positive mice macrophages.Parasitology research · 2005Article
- Evaluating spleen volume in inflammatory bowel disease.Annals of gastroenterologyReview
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mice infected with a macrophagotropic strain of Trypanosoma cruzi develop progressive splenomegaly due to reactive hyperplasia with increased number of lymphocytes and macrophages, culminating in parasite disintegration and necrosis of parasitized cells. Necrotic changes have been attributed to the liberation of toxic cytokines, including TNF-alpha, from parasitized macrophages. In the present study, the presence of TNF-alpha was investigated in situ. In addition the participation of destroyed parasites in inducing the liberation of TNF-alpha was examined in two highly susceptible mice strains (C3H and Swiss) and a more resistant strain (DBA). Swiss (90) C3H/He (83) and DBA (30) mice were infected with the Peruvian strain of T. cruzi. Nineteen infected Swiss mice, and 22 infected C3H/He were treated with Benznidazole (one or two doses, 100 mg/kg bw/day), on the 8th and 9th days after infection. Necrotic splenic lesions occurred in both susceptible and resistant strains of mice. Although differing in degree, lesions were more intense in C3H and Swiss than in DBA mice. Comparing untreated and treated susceptible mice, necrotic lesions were significantly less intense in the latter. By specific monoclonal antibody immunolabelling, TNF-alpha was demonstrated in the cytoplasm of macrophages and within necrotic areas, from Swiss, C3H/He and DBA mouse spleens. In conclusion, TNF-alpha, probably synthesized by macrophages, was strongly expressed at the sites of parasite and cell destruction, thus appearing to play a pivotal role in splenic necrotic changes associated with severe experimental T. cruzi infection.
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