ArticleAmerican journal of human genetics2002
Ethnic-difference markers for use in mapping by admixture linkage disequilibrium.
Article in American journal of human genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00005340 (Hypertension in Blacks of West African Origin), which is not on this map. Cited by 58 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Hypertension in Blacks of West African Origin
Who cites it
58 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Race and ethnicity in genetic research.American journal of medical genetics. Part A · 2007Pooled it
- Trial
- Influence of Genetic West African Ancestry on Metabolomics among Hypertensive Patients.Metabolites · 2022Article
- Estimating Genetic Relatedness in Admixed Populations.G3 (Bethesda, Md.) · 2018Article
- A panel of 130 autosomal single-nucleotide polymorphisms for ancestry assignment in five Asian populations and in Caucasians.Forensic science, medicine, and pathology · 2017Article
- Admixture mapping of tuberculosis and pigmentation-related traits in an African-European hybrid cattle population.Frontiers in genetics · 2015Article
- Article
- Transposable element polymorphisms recapitulate human evolution.Mobile DNA · 2015Article
- Mapping asthma-associated variants in admixed populations.Frontiers in genetics · 2015Review
- Trans-ethnic genome-wide association studies: advantages and challenges of mapping in diverse populations.Genome medicine · 2014Article
- Extensive ethnogenomic diversity of endothelial nitric oxide synthase (eNOS) polymorphisms.Gene regulation and systems biology · 2013Article
- Adrenergic-pathway gene variants influence beta-blocker-related outcomes after acute coronary syndrome in a race-specific manner.Journal of the American College of Cardiology · 2012Article
- Human population admixture in Asia.Genomics & informatics · 2012Article
- AncestrySNPminer: a bioinformatics tool to retrieve and develop ancestry informative SNP panels.Genomics · 2012Article
- Comparison of measures of marker informativeness for ancestry and admixture mapping.BMC genomics · 2011Article
- Stronger bone correlates with African admixture in African-American women.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2011Article
- Interactions among genes, tumor biology and the environment in cancer health disparities: examining the evidence on a national and global scale.Carcinogenesis · 2011Review
- Wide disparity in genetic admixture among Mexican Americans from San Antonio, TX.Annals of human genetics · 2011Article
- Article
- Race as a social construct in head and neck cancer outcomes.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2011Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Mapping by admixture linkage disequilibrium (MALD) is a potentially powerful technique for the mapping of complex genetic diseases. The practical requirements of this method include (a) a set of markers spanning the genome that have large allele-frequency differences between the parental ethnicities contributing to the admixed population and (b) an understanding of the extent of admixture in the study population. To this end, a DNA-pooling technique was used to screen microsatellite and diallelic insertion/deletion markers for allele-frequency differences between putative representatives of the parental populations of the admixed Mexican American (MA) and African American (AA) populations. Markers with promising pooled differences were then confirmed by individual genotyping in both the parental and admixed populations. For the MA population, screening of >600 markers identified 151 ethnic-difference markers (EDMs) with delta>0.30 (where delta is the absolute value of each allele-frequency difference between two populations, summed over all marker alleles and divided by two) that are likely to be useful for MALD analysis. For the AA population, analysis of >400 markers identified 97 EDMs. In addition, individual genotyping of these markers in Pima Amerindians, Yavapai Amerindians, European American (EA) individuals, Africans from Zimbabwe, MA individuals, and AA individuals, as well as comparison to the CEPH genotyping set, suggests that the differences between subpopulations of an ethnicity are small for many markers with large interethnic differences. Estimates of admixture that are based on individual genotyping of these markers are consistent with a 60% EA:40% Amerindian contribution to MA populations and with a 20% EA:80% African contribution to AA populations. Taken together, these data suggest that EDMs with large interpopulation and small intrapopulation differences can be readily identified for MALD studies in both AA and MA populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.