ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
Segmental pattern of myocardial sympathetic denervation in idiopathic dilated cardiomyopathy: relationship to regional wall motion and myocardial perfusion abnormalities.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- 123I-mIBG scintigraphy to predict risk for adverse cardiac outcomes in heart failure patients: design of two prospective multicenter international trials.Journal of nuclear cardiology : official publication of the American Society of Nuclear CardiologyTrial
- Normal values and within-subject variability of cardiac I-123 MIBG scintigraphy in healthy individuals: implications for clinical studies.Journal of nuclear cardiology : official publication of the American Society of Nuclear CardiologyTrial
- Redefining Sudden Cardiac Death Risk Stratification in Dilated Cardiomyopathy: An Integrative Approach.Reviews in cardiovascular medicine · 2026Review
- Enhanced cardiac sympathetic innervation predicts systolic function improvement and outcome in dilated cardiomyopathy.Cardiology journal · 2026Article
- Bayliss Starling Prize Lecture 2023: Neuropeptide-Y being 'unsympathetic' to the broken hearted.The Journal of physiology · 2025Article
- Sympathetic Modulation in Cardiac Arrhythmias: Where We Stand and Where We Go.Journal of personalized medicine · 2023Review
- Modified Algorithm Using Total Count for Calculating Myocardial Washout Rate in Single-Photon Emission Computerized Tomography.Annals of nuclear cardiology · 2023Article
- Prognostic value of summed motion score assessed by gated SPECT myocardial perfusion imaging in patients with dilated cardiomyopathy.Frontiers in cardiovascular medicine · 2023Article
- Autonomic Regulation and Ventricular Arrhythmias.Current treatment options in cardiovascular medicine · 2018Review
- Cardiac metaiodobenzylguanidine imaging and heart failure.Current heart failure reports · 2013Review
- I -123 metaiodobenzylguanidine imaging for predicting ventricular arrhythmia in heart failure patients.Journal of biomedical research · 2013Review
- Semi-automated algorithm for calculating heart-to-mediastinum ratio in cardiac Iodine-123 MIBG imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2011Article
- Impact of mediastinal, liver and lung (123)I-metaiodobenzylguanidine ( (123)I-MIBG) washout on calculated (123)I-MIBG myocardial washout.European journal of nuclear medicine and molecular imaging · 2009Article
- Evaluating presynaptic and postsynaptic innervation in heart failure.Current cardiology reports · 2009Review
- Variations in 123I-metaiodobenzylguanidine (MIBG) late heart mediastinal ratios in chronic heart failure: a need for standardisation and validation.European journal of nuclear medicine and molecular imaging · 2008Article
- I-123-mIBG myocardial imaging for assessment of risk for a major cardiac event in heart failure patients: insights from a retrospective European multicenter study.European journal of nuclear medicine and molecular imaging · 2008Article
- I-123 MIBG scintigraphy in idiopathic dilated cardiomyopathy: where next?Journal of nuclear cardiology : official publication of the American Society of Nuclear CardiologyArticle
- The role of the autonomic nervous system in sudden cardiac death.Progress in cardiovascular diseasesReview
- Regional alterations in myocardial sympathetic innervation in patients with transient left-ventricular apical ballooning (Tako-Tsubo cardiomyopathy).Journal of nuclear cardiology : official publication of the American Society of Nuclear CardiologyArticle
- Cardiac receptor physiology and imaging: an update.Journal of nuclear cardiology : official publication of the American Society of Nuclear CardiologyArticle
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIodine 123-labeled metaiodobenzylguanidine (MIBG) has been used to study cardiac adrenergic nerve activity. Cardiac MIBG uptake is diminished in patients with heart failure. However, it is not known how this reduction is related to regional abnormalities of myocardial wall motion or perfusion. METHODS AND
resultsWe studied 24 patients with idiopathic dilated cardiomyopathy (ejection fraction <45%) and 15 healthy control subjects using I-123 MIBG cardiac imaging, echocardiographic assessment of wall motion abnormalities, technetium 99m sestamibi perfusion scintigraphy, and hemodynamic assessment. Cardiac MIBG was significantly correlated with ejection fraction (r = 0.67), cardiac index (r = 0.57), left ventricular wall motion score index (r = -0.68), and systolic wall stress (r = -0.61). MIBG was lower in patients than in control subjects (1.43 +/- 0.19 vs 2.05 +/- 0.02; P <.01), whereas the washout rate was higher (P <.01). Moreover, a significant correlation was found between the reduction in MIBG uptake and the severity of echocardiographic wall motion abnormalities in the anterior wall (r = 0.543), apex (r = 0.530), and septum (r = 0.675), as well as with the severity of decrease in resting myocardial perfusion in the anterior wall (r = 0.480) and septum (r = 0.580).
conclusionsPatients with idiopathic dilated cardiomyopathy show not only global but also regional abnormalities of cardiac sympathetic innervation. The severity of these changes is partially correlated with abnormalities of regional wall motion and myocardial perfusion.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.