ArticleProceedings of the National Academy of Sciences of the United States of America2002
Interactions between double positive thymocytes and high affinity ligands presented by cortical epithelial cells generate double negative thymocytes with T cell regulatory activity.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 50 citations in OpenAlex.
- CD3Frontiers in immunology · 2022Review
- HIV Infection and Persistence in Pulmonary Mucosal Double Negative T CellsJournal of virology · 2020Article
- DNT Cell-based Immunotherapy: Progress and Applications.Journal of Cancer · 2020Review
- Temporal Expression of Bim Limits the Development of Agonist-Selected Thymocytes and Skews Their TCRβ Repertoire.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- MHC class II restricted innate-like double negative T cells contribute to optimal primary and secondary immunity to Leishmania major.PLoS pathogens · 2014Article
- The unique surface molecules on intestinal intraepithelial lymphocytes: from tethering to recognizing.Digestive diseases and sciences · 2014Review
- Clonal deletion and the fate of autoreactive thymocytes that survive negative selection.Nature immunology · 2012Article
- Double-negative T cells during HIV/SIV infections: potential pinch hitters in the T-cell lineup.Current opinion in HIV and AIDS · 2012Review
- The light and dark sides of intestinal intraepithelial lymphocytes.Nature reviews. Immunology · 2011Review
- Double negative (CD3+ 4- 8-) TCR alphabeta splenic cells from young NOD mice provide long-lasting protection against type 1 diabetes.PloS one · 2010Article
- Double-negative regulatory T cells: non-conventional regulators.Immunologic research · 2006Review
- The timing of TCR alpha expression critically influences T cell development and selection.The Journal of experimental medicine · 2005Article
- Regulatory T cell-mediated transplantation tolerance.Immunologic research · 2005Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Previous studies on thymocyte differentiation by using reaggregate cultures (RC) of double positive T cell receptor (TCR) transgenic thymocytes and the thymic epithelial cell line ANV indicated that low concentrations of high affinity ligands for the TCR were efficient inducers of thymocyte maturation to CD4 single positive (SP) functional cells. In this study, it is demonstrated that, when high concentrations of high affinity ligands are used in this RC system, double positive (DP) cells down-modulate expression of both coreceptors and that, as a result, large numbers of double negative (DN) cells are generated. These DN cells proliferated modestly in response to stimulation by antigen, and this response was considerably augmented by the addition of IL-2 to the cultures. Notably, these antigen-stimulated DN cells produced large amounts of IL-10. When the DN cells generated in RC were cocultured with naive TCR transgenic T cells in the presence of antigen, they suppressed the proliferative response of the naive T cells. Thus, high affinity ligands, when presented to DP thymocytes by cortical thymic epithelial cells in reaggregate cultures, rather than causing deletion of the immature thymocytes, induce their differentiation into immunoregulatory DN cells, suggesting a distinct mechanism by which self tolerance may be maintained.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.