ArticleProceedings of the National Academy of Sciences of the United States of America2002
Discrimination of MHC-derived odors by untrained mice is consistent with divergence in peptide-binding region residues.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 80 citations in OpenAlex.
- Lymphocytic Choriomeningitis Virus Alters the Expression of Male Mouse Scent Proteins.Viruses · 2021Article
- No evidence for MHC class II-based non-random mating at the gametic haplotype in Atlantic salmon.Heredity · 2017Article
- MHC-dependent mate choice is linked to a trace-amine-associated receptor gene in a mammal.Scientific reports · 2016Article
- Of volatiles and peptides: in search for MHC-dependent olfactory signals in social communication.Cellular and molecular life sciences : CMLS · 2014Review
- Mate choice for genetic compatibility in the house mouse.Ecology and evolution · 2013Article
- Mouse urinary peptides provide a molecular basis for genotype discrimination by nasal sensory neurons.Nature communications · 2013Article
- Selection and phylogenetics of salmonid MHC class I: wild brown trout (Salmo trutta) differ from a non-native introduced strain.PloS one · 2013Article
- Social discrimination by quantitative assessment of immunogenetic similarity.Proceedings. Biological sciences · 2012Article
- Major histocompatibility complex class II compatibility, but not class I, predicts mate choice in a bird with highly developed olfaction.Proceedings. Biological sciences · 2012Article
- Why must T cells be cross-reactive?Nature reviews. Immunology · 2012Review
- MHC signaling during social communication.Advances in experimental medicine and biology · 2012Article
- Major histocompatibility complex class IIA and IIB genes of the spotted halibut Verasper variegatus: genomic structure, molecular polymorphism, and expression analysis.Fish physiology and biochemistry · 2011Article
- In search of the chemical basis for MHC odourtypes.Proceedings. Biological sciences · 2010Review
- Self/nonself perception, reproduction and the extended MHC.Self/nonself · 2010Article
- Cryptic preference for MHC-dissimilar females in male red junglefowl, Gallus gallus.Proceedings. Biological sciences · 2009Article
- Evidence of disassortative mating in a Tanganyikan cichlid fish and its role in the maintenance of intrapopulation dimorphism.Biology letters · 2008Article
- The genetic basis of inbreeding avoidance in house mice.Current biology : CB · 2007Article
- Article
- Quantitative analysis of mouse urine volatiles: in search of MHC-dependent differences.PloS one · 2007Article
- Chemical identification of MHC-influenced volatile compounds in mouse urine. I: Quantitative Proportions of Major Chemosignals.Journal of chemical ecology · 2007Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genes of the major histocompatibility complex (MHC) play a central role in immune recognition, yet they also influence the odor of individuals. Mice can be trained to distinguish odors mediated by classical MHC loci; however, training can introduce confounding behavioral artifacts. This study demonstrates that mice can distinguish some, but not all, naturally occurring allelic variants at classical MHC loci without prior training. This result suggests that MHC-disassortative mating preferences might operate by means of small MHC-based odor differences, and could therefore contribute to diversifying selection acting on MHC loci. Here we show that odors of two MHC mutant mouse strains (bm1 and bm3) can be distinguished, even after genetic background is controlled by intercrossing strains. These two strains differ by five amino acids, three of which are predicted to chemically contact peptides bound to the peptide-binding region (PBR), the site of antigen presentation for T cell recognition. However, the odors of neither bm1 nor bm3 were distinguished from their parental B6 haplotype after randomizing genomic background, despite discrimination of pure-bred B6 and bm1 strain odors. These combined results suggest that (i) there may be an MHC odor discrimination threshold based on divergence in PBR residues, providing a more logical pattern of MHC-based odor discrimination than found in previous training studies, where discrimination ability was not correlated with PBR divergence; and (ii) additional (non-MHC) mutations that influence odor have accumulated in these strains during the 100 generations of divergence between pure B6 and bm1 strains.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.