ArticlePlant physiology2002
Resistance against herbicide isoxaben and cellulose deficiency caused by distinct mutations in same cellulose synthase isoform CESA6.
Article in Plant physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 132 papers.
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Who cites it
132 citing papers in PubMed, 298 citations in OpenAlex.
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- Molecular insights into avocado grafting: the role of chitinase-like genes.Plant physiology · 2026Article
- Ubiquitination of the ribosomal-like domain of UBIQUITIN6 contributes to cell wall stress responses in Arabidopsis.The Plant cell · 2026Article
- A fungal natural product that inhibits plant cellulose biosynthesis by disrupting cellulose synthase complexes.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Evolution and Future Directions in Herbicide-Resistant Crop Development and Weed Management.Rice (New York, N.Y.) · 2025Review
- REM transcription factors and GDE1 shape the DNA methylation landscape through the recruitment of RNA polymerase IV transcription complexes.Nature cell biology · 2025Article
- A peptide-receptor module links cell wall integrity sensing to pattern-triggered immunity.Nature plants · 2024Article
- Identifying genetic determinants of forage sorghum [Sorghum bicolor (Moench)] adaptation through GWAS.BMC plant biology · 2024Article
- The fnr-like mutants confer isoxaben tolerance by initiating mitochondrial retrograde signalling.Plant biotechnology journal · 2024Article
- Cell wall integrity modulates HOOKLESS1 and PHYTOCHROME INTERACTING FACTOR4 expression controlling apical hook formation.Plant physiology · 2024Article
- A cellulose synthesis inhibitor affects cellulose synthase complex secretion and cortical microtubule dynamics.Plant physiology · 2024Article
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- A self-regulatory cell-wall-sensing module at cell edges controls plant growth.Nature plants · 2024Article
- Cellulose biosynthesis inhibitor isoxaben causes nutrient-dependent and tissue-specific Arabidopsis phenotypes.Plant physiology · 2024Article
- Transcriptomic Evidence of a Link between Cell Wall Biogenesis, Pathogenesis, and Vigor in Walnut Root and Trunk Diseases.International journal of molecular sciences · 2024Article
- Tissue-Specific Transcriptomes in the Secondary Cell Wall Provide an Understanding of Stem Growth Enhancement inBiology · 2023Article
- Identification ofGenes · 2023Article
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- Cell wall integrity regulation across plant species.Plant molecular biology · 2022Review
72 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Isoxaben is a pre-emergence herbicide that inhibits cellulose biosynthesis in higher plants. Two loci identified by isoxaben-resistant mutants (ixr1-1, ixr1-2, and ixr2-1) in Arabidopsis have been reported previously. IXR1 was recently shown to encode the cellulose synthase catalytic subunit CESA3 (W.-R. Scheible, R. Eshed, T. Richmond, D. Delmer, and C. Somerville [2001] Proc Natl Acad Sci USA 98: 10079-10084). Here, we report on the cloning of IXR2, and show that it encodes another cellulose synthase isoform, CESA6. ixr2-1 carries a mutation substituting an amino acid close to the C terminus of CESA6 that is highly conserved among CESA family members. Transformation of wild-type plants with the mutated gene and not with the wild-type gene conferred increased resistance against the herbicide. The simplest interpretation for the existence of these two isoxaben-resistant loci is that CESA3 and CESA6 have redundant functions. However, loss of function procuste1 alleles of CESA6 were previously shown to have a strong growth defect and reduced cellulose content in roots and dark-grown hypocotyls. This indicates that in these mutants, the presence of CESA3 does not compensate for the absence of CESA6 in roots and dark-grown hypocotyls, which argues against redundant functions for CESA3 and CESA6. Together, these observations are compatible with a model in which CESA6 and CESA3 are active as a protein complex.
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