ArticleMolecular psychiatry2002
The Wellcome trust UK-Irish bipolar affective disorder sibling-pair genome screen: first stage report.
Article in Molecular psychiatry, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- Pooled it
- Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder.American journal of human genetics · 2003Pooled it
- Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia.Molecular psychiatry · 2002Pooled it
- Chromosome 18p11.2 harbors susceptibility marker: D18S452, for bipolar affective disorder.Indian journal of psychiatry · 2013Article
- Genome-wide searches for bipolar disorder genes.Current psychiatry reports · 2011Article
- Association analysis between polymorphisms in the myo-inositol monophosphatase 2 (IMPA2) gene and bipolar disorder.Progress in neuro-psychopharmacology & biological psychiatry · 2010Article
- Evidence for rare and common genetic risk variants for schizophrenia at protein kinase C, alpha.Molecular psychiatry · 2010Article
- An investigation of candidate regions for association with bipolar disorder.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2010Article
- Association between polymorphisms in the metallophosphoesterase (MPPE1) gene and bipolar disorder.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2010Article
- Association between polymorphisms in the vesicle-associated membrane protein-associated protein A (VAPA) gene on chromosome 18p and bipolar disorder.Journal of neural transmission (Vienna, Austria : 1996) · 2008Article
- The genetics of bipolar disorder: genome 'hot regions,' genes, new potential candidates and future directions.Molecular psychiatry · 2008Review
- Susceptibility of schizophrenia and affective disorder not associated with loci on chromosome 6q in Han Chinese population.Behavioral and brain functions : BBF · 2007Article
- Dense SNP association study for bipolar I disorder on chromosome 18p11 suggests two loci with excess paternal transmission.Molecular psychiatry · 2007Article
- Positional cloning, association analysis and expression studies provide convergent evidence that the cadherin gene FAT contains a bipolar disorder susceptibility allele.Molecular psychiatry · 2006Article
- A genome-wide approach to identify genetic loci with a signature of natural selection in the Irish population.Genome biology · 2006Article
- Excitement and confusion on chromosome 6q: the challenges of neuropsychiatric genetics in microcosm.Molecular psychiatry · 2005Review
- Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q.American journal of human genetics · 2005Article
- Assessment of the effect of age at onset on linkage to bipolar disorder: evidence on chromosomes 18p and 21q.American journal of human genetics · 2005Article
- Stage 2 of the Wellcome Trust UK-Irish bipolar affective disorder sibling-pair genome screen: evidence for linkage on chromosomes 6q16-q21, 4q12-q21, 9p21, 10p14-p12 and 18q22.Molecular psychiatry · 2005Article
- Genomewide scan for affective disorder susceptibility Loci in families of a northern Swedish isolated population.American journal of human genetics · 2005Article
Corrections and comments
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Authors and funding
22 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have completed the first stage of a two-stage genome wide screen designed to identify chromosomal regions that may harbour susceptibility genes for bipolar affective disorder. The first stage screening sample included 509 subjects from 151 nuclear families recruited within the United Kingdom and Republic of Ireland. This sample contained 154 narrowly defined affected sibling pairs (DSM-IV BPI) and 258 broadly defined affected sibling pairs (DSM-IV BPI, SABP, BPII, BPNOS or MDD(R)), approximately two thirds of all families contained at least one other additional typed individual. All individuals were genotyped using 398 highly polymorphic microsatellite markers from Applied Biosystems's Linkage Mapping Set Version 2. The average inter-marker distance was 9.6 cM and the mean heterozygosity was 0.78. Analysis of these data using non-parametric linkage methods (MAPMAKER/SIBS) found no evidence for loci of major effect and no regions reached genome-wide significance for either suggestive or significant linkage. We identified 19 points across the genome where the MLS exceeded a value set for follow up in our second stage screen (MLS > or = 0.74 (equivalent to a nominal pointwise significance of 5%) under the narrowest diagnostic model). These points were on chromosomes 2, 3, 4, 6, 7, 9, 10, 12, 17, 18 & X. Some of these points overlapped with previous linkage reports both within bipolar affective disorder and other psychiatric illnesses. Under the narrowest diagnostic model, the single most significant multipoint linkage was on chromosome 18 at marker D18S452 (MLS=1.54). Overall the highest MLS was 1.70 on chromosome 2 at marker D2S125, under the broadest diagnostic model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.