ArticleMolecular psychiatry2002
Segmental linkage disequilibrium within the dopamine transporter gene.
Article in Molecular psychiatry, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Candidate gene studies of ADHD: a meta-analytic review.Human genetics · 2009Pooled it
- Identification of additional variants within the human dopamine transporter gene provides further evidence for an association with bipolar disorder in two independent samples.Molecular psychiatry · 2006Trial
- Dopamine transporter haplotype and attention-deficit hyperactivity disorder.Molecular psychiatry · 2005Trial
- Carriers of a common variant in the dopamine transporter gene have greater dementia risk, cognitive decline, and faster ventricular expansion.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2015Article
- Dopamine transporter gene may be associated with bipolar disorder and its personality traits.European archives of psychiatry and clinical neuroscience · 2015Article
- Association of dopamine transporter gene variants with childhood ADHD features in bipolar disorder.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2013Article
- Genetically determined dopamine availability predicts disposition for depression.Brain and behavior · 2011Article
- The effect of reduced dopamine D4 receptor expression in the 5-choice continuous performance task: Separating response inhibition from premature responding.Behavioural brain research · 2011Article
- Genomic features of the human dopamine transporter gene and its potential epigenetic States: implications for phenotypic diversity.PloS one · 2010Article
- SLC6A3 and body mass index in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial.BMC medical genetics · 2009Article
- Family-based study of markers at the 5'-flanking region of the human dopamine transporter gene reveals potential association with schizophrenic psychoses.European archives of psychiatry and clinical neuroscience · 2006Article
- A dopamine transporter gene functional variant associated with cocaine abuse in a Brazilian sample.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Attention-Deficit Hyperactivity Disorder in the post-genomic era.European child & adolescent psychiatry · 2004Article
- Linkage disequilibrium mapping at DAT1, DRD5 and DBH narrows the search for ADHD susceptibility alleles at these loci.Molecular psychiatry · 2003Article
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 2 countries.
Funding
Abstract
The dopamine transporter gene (DAT) has been implicated in a variety of disorders, including bipolar disorder, attention-deficit hyperactivity disorder, cocaine-induced paranoia, Tourette's syndrome, and Parkinson's disease. As no clear functional polymorphism has been identified to date, studies rely on linkage disequilibrium (LD) to assess the possible genetic contribution of DAT to the various disorders. A better understanding of the complex structure of LD across the gene is thus critical for an accurate interpretation of the results of such studies, and may facilitate the mapping of the actual functional variants. In the process of characterizing the extent of variation within the DAT gene, we have identified a number of single nucleotide polymorphisms (SNPs) suitable for LD studies, 14 of which have been analyzed, along with a 3' repeat polymorphism, in a sample of 120 parent-proband triads. Calculations of pairwise LD between the SNPs in the parental haplotypes revealed a high degree of LD (P < 0.00001) in the 5' (distal promoter through intron 6) and 3' (exon 9 through exon 15) regions of DAT. This segmental LD pattern is maintained over approximately 27 kb and 20 kb in these two regions, respectively, with very little significant LD between them, possibly due to the presence of a recombination hotspot located near the middle of the gene. These analyses of the DAT gene thus reveal a complex structure resulting from both recombination and mutation, knowledge of which may be invaluable to the design of future studies.
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