ArticleMolecular and cellular biology2002
Ultrastructural cartilage abnormalities in MIA/CD-RAP-deficient mice.
Article in Molecular and cellular biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 46 citations in OpenAlex.
- MIA/CD-RAP Regulates MMP13 and Is a Potential New Disease-Modifying Target for Osteoarthritis Therapy.Cells · 2023Article
- Digits in a dish: AnFrontiers in cell and developmental biology · 2023Article
- Dual-Source Computed Tomography Evaluation of Children with Congenital Pulmonary Valve Stenosis.Iranian journal of radiology : a quarterly journal published by the Iranian Radiological Society · 2016Article
- Drug-induced regeneration in adult mice.Science translational medicine · 2015Article
- Activating enhancer binding protein 2 epsilon (AP-2ε)-deficient mice exhibit increased matrix metalloproteinase 13 expression and progressive osteoarthritis development.Arthritis research & therapy · 2015Article
- YBX1 is a modulator of MIA/CD-RAP-dependent chondrogenesis.PloS one · 2013Article
- Targeting melanoma metastasis and immunosuppression with a new mode of melanoma inhibitory activity (MIA) protein inhibition.PloS one · 2012Article
- Pitfalls in immunohistochemistry--a recent example.International journal of clinical and experimental pathology · 2012Article
- Protein export at the ER: loading big collagens into COPII carriers.The EMBO journal · 2011Review
- Global defects in collagen secretion in a Mia3/TANGO1 knockout mouse.The Journal of cell biology · 2011Article
- Enhanced cartilage regeneration in MIA/CD-RAP deficient mice.Cell death & disease · 2010Article
- Modulation of cartilage differentiation by melanoma inhibiting activity/cartilage-derived retinoic acid-sensitive protein (MIA/CD-RAP).Experimental & molecular medicine · 2010Article
- Misexpression of MIA disrupts lung morphogenesis and causes neonatal death.Developmental biology · 2008Article
- Monitoring cartilage turnover.Current rheumatology reports · 2007Review
- Microarray analysis of the rat lacrimal gland following the loss of parasympathetic control of secretion.Physiological genomics · 2004Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MIA/CD-RAP is a small, soluble protein secreted from malignant melanoma cells and from chondrocytes. Recent evidence has identified MIA/CD-RAP as the prototype of a small family of extracellular proteins adopting an SH3 domain-like fold. It is thought that interaction between MIA/CD-RAP and specific epitopes in extracellular matrix proteins regulates the attachment of tumor cells and chondrocytes. In order to study the consequences of MIA/CD-RAP deficiency in vivo, we generated mice with a targeted gene disruption. The complete absence of MIA/CD-RAP mRNA and protein expression was demonstrated by reverse transcriptase, Western blot analysis, and enzyme-linked immunosorbent assay measurements of whole-embryo extracts. MIA(-/-) mice were viable and developed normally, and histological examination of the organs by means of light microscopy revealed no major abnormalities. In contrast, electron microscopic studies of cartilage composition revealed subtle defects in collagen fiber density, diameter, and arrangement, as well as changes in the number and morphology of chondrocytic microvilli. Taken together, our data indicate that MIA/CD-RAP is essentially required for formation of the highly ordered ultrastructural fiber architecture in cartilage and may have a role in regulating chondrocyte matrix interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.