ArticleMolecular and cellular biology2002
Apoptotic regulation by the Crk adapter protein mediated by interactions with Wee1 and Crm1/exportin.
Article in Molecular and cellular biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Structural Investigations of Interactions between the Influenza a Virus NS1 and Host Cellular Proteins.Viruses · 2023Review
- Synthetic and Medicinal Chemistry Approaches Toward WEE1 Kinase Inhibitors and Its Degraders.ACS omega · 2023Review
- Article
- Pseudomonas aeruginosa ExoT Induces Atypical Anoikis Apoptosis in Target Host Cells by Transforming Crk Adaptor Protein into a Cytotoxin.PLoS pathogens · 2015Article
- The Role of Crk Adaptor Proteins in T-Cell Adhesion and Migration.Frontiers in immunology · 2015Review
- Contribution of Crk adaptor proteins to host cell and bacteria interactions.BioMed research international · 2014Review
- The adaptor protein CRK is a pro-apoptotic transducer of endoplasmic reticulum stress.Nature cell biology · 2011Article
- CrkL is a co-activator of estrogen receptor alpha that enhances tumorigenic potential in cancer.Molecular endocrinology (Baltimore, Md.) · 2011Article
- Distinct roles for Crk adaptor isoforms in actin reorganization induced by extracellular signals.Journal of cell science · 2009Article
- Crk and CrkL adaptor proteins: networks for physiological and pathological signaling.Cell communication and signaling : CCS · 2009Article
- Loss of cryptochrome reduces cancer risk in p53 mutant mice.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Focal adhesion components are essential for mammalian cell cytokinesis.Cell cycle (Georgetown, Tex.) · 2008Article
- Cell cycle regulation by the Wee1 inhibitor PD0166285, pyrido [2,3-d] pyimidine, in the B16 mouse melanoma cell line.BMC cancer · 2006Article
- Solution structure and folding characteristics of the C-terminal SH3 domain of c-Crk-II.Biochemistry · 2006Article
- Transactivation of Abl by the Crk II adapter protein requires a PNAY sequence in the Crk C-terminal SH3 domain.Oncogene · 2005Article
- Akt/protein kinase B-dependent phosphorylation and inactivation of WEE1Hu promote cell cycle progression at G2/M transition.Molecular and cellular biology · 2005Article
- Cytoplasmic c-Abl provides a molecular 'Rheostat' controlling carcinoma cell survival and invasion.Oncogene · 2003Article
- CrkII induces serum response factor activation and cellular transformation through its function in Rho activation.Oncogene · 2003Article
- CrkIII: a novel and biologically distinct member of the Crk family of adaptor proteins.Oncogene · 2003Article
- Involvement of crk adapter proteins in regulation of lymphoid cell functions.Immunologic research · 2003Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
The adapter protein Crk contains an SH2 domain and two SH3 domains. Through binding of particular ligands to the SH2 domain and the N-terminal SH3 domain, Crk has been implicated in a number of signaling processes, including regulation of cell growth, cell motility, and apoptosis. We report here that the C-terminal SH3 domain, never shown to bind any specific signaling molecules, contains a binding site for the nuclear export factor Crm1. We find that a mutant Crk protein, deficient in Crm1 binding, promotes apoptosis. Moreover, this nuclear export sequence mutant [NES(-) Crk] interacts strongly, through its SH2 domain, with the nuclear tyrosine kinase, Wee1. Collectively, these data suggest that a nuclear population of Crk bound to Wee1 promotes apoptotic death of mammalian cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.