ArticleMolecular and cellular biology2002
ARF differentially modulates apoptosis induced by E2F1 and Myc.
Article in Molecular and cellular biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 71 citations in OpenAlex.
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- p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
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- p53 and E2f: partners in life and death.Nature reviews. Cancer · 2009Review
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- Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development.Developmental cell · 2008Article
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- E2F1 induces MRN foci formation and a cell cycle checkpoint response in human fibroblasts.Oncogene · 2006Article
- E2F1 suppresses skin carcinogenesis via the ARF-p53 pathway.Oncogene · 2006Article
- ATM promotes apoptosis and suppresses tumorigenesis in response to Myc.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Cell cycle-dependent nuclear retention of p53 by E2F1 requires phosphorylation of p53 at Ser315.The EMBO journal · 2005Article
- Regulation of epidermal apoptosis and DNA repair by E2F1 in response to ultraviolet B radiation.Oncogene · 2005Article
- The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Selection of novel mediators of E2F1-induced apoptosis through retroviral expression of an antisense cDNA library.Nucleic acids research · 2005Article
- Loss of one allele of ARF rescues Mdm2 haploinsufficiency effects on apoptosis and lymphoma development.Oncogene · 2004Article
- Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The ARF tumor suppressor participates in a p53-dependent apoptotic pathway that is stimulated in response to some oncogenic stimuli. The E2F1 transcription factor is a critical downstream target of the Rb tumor suppressor and, when active, can promote proliferation as well as apoptosis. The finding that E2F1 transcriptionally regulates the ARF gene has led to the suggestion that ARF contributes to E2F1-induced apoptosis. Counter to this hypothesis, this study demonstrates not only that ARF is unnecessary for E2F1 to induce apoptosis but also that inactivation of ARF actually enhances the ability of E2F1 to promote apoptosis. Inactivation of ARF also cooperates with E2F1 activity to promote entry into the S phase of the cell cycle. This relationship between ARF and E2F1 is demonstrated in transgenic epidermis in vivo and in mouse embryo fibroblast cultures in vitro. In contrast, the ability of Myc to induce apoptosis is diminished in the absence of ARF. E2F1 induces the accumulation of p53 in the absence of ARF, and this is associated with the phosphorylation of p53 on several residues. These findings demonstrate that ARF is a negative regulator of E2F1 activity and is not required for E2F1-induced apoptosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.